Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.

Coordinate autophagy and mTOR pathway inhibition enhances cell death in melanoma.

The phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway promotes melanoma tumor growth and survival while suppressing autophagy, a catabolic process through which cells collect and recycle cellular components to sustain energy homeostasis in starvation. Conversely...

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Autores principales: Xiaoqi Xie, Eileen P White, Janice M Mehnert
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/84f0e283748e4d67bc8d9c5dac538f48
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