A causal role for the right frontal eye fields in value comparison

Recent studies have suggested close functional links between overt visual attention and decision making. This suggests that the corresponding mechanisms may interface in brain regions known to be crucial for guiding visual attention – such as the frontal eye field (FEF). Here, we combined brain stim...

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Autores principales:	Ian Krajbich, Andres Mitsumasu, Rafael Polania, Christian C Ruff, Ernst Fehr
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	attention eye tracking brain stimulation drift diffusion model decision making frontal eye fields Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/84f191d477e24f81aba79f74498f5dd3
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id	oai:doaj.org-article:84f191d477e24f81aba79f74498f5dd3
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spelling	oai:doaj.org-article:84f191d477e24f81aba79f74498f5dd32021-11-15T16:31:12ZA causal role for the right frontal eye fields in value comparison10.7554/eLife.674772050-084Xe67477https://doaj.org/article/84f191d477e24f81aba79f74498f5dd32021-11-01T00:00:00Zhttps://elifesciences.org/articles/67477https://doaj.org/toc/2050-084XRecent studies have suggested close functional links between overt visual attention and decision making. This suggests that the corresponding mechanisms may interface in brain regions known to be crucial for guiding visual attention – such as the frontal eye field (FEF). Here, we combined brain stimulation, eye tracking, and computational approaches to explore this possibility. We show that inhibitory transcranial magnetic stimulation (TMS) over the right FEF has a causal impact on decision making, reducing the effect of gaze dwell time on choice while also increasing reaction times. We computationally characterize this putative mechanism by using the attentional drift diffusion model (aDDM), which reveals that FEF inhibition reduces the relative discounting of the non-fixated option in the comparison process. Our findings establish an important causal role of the right FEF in choice, elucidate the underlying mechanism, and provide support for one of the key causal hypotheses associated with the aDDM.Ian KrajbichAndres MitsumasuRafael PolaniaChristian C RuffErnst FehreLife Sciences Publications Ltdarticleattentioneye trackingbrain stimulationdrift diffusion modeldecision makingfrontal eye fieldsMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	attention eye tracking brain stimulation drift diffusion model decision making frontal eye fields Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	attention eye tracking brain stimulation drift diffusion model decision making frontal eye fields Medicine R Science Q Biology (General) QH301-705.5 Ian Krajbich Andres Mitsumasu Rafael Polania Christian C Ruff Ernst Fehr A causal role for the right frontal eye fields in value comparison
description	Recent studies have suggested close functional links between overt visual attention and decision making. This suggests that the corresponding mechanisms may interface in brain regions known to be crucial for guiding visual attention – such as the frontal eye field (FEF). Here, we combined brain stimulation, eye tracking, and computational approaches to explore this possibility. We show that inhibitory transcranial magnetic stimulation (TMS) over the right FEF has a causal impact on decision making, reducing the effect of gaze dwell time on choice while also increasing reaction times. We computationally characterize this putative mechanism by using the attentional drift diffusion model (aDDM), which reveals that FEF inhibition reduces the relative discounting of the non-fixated option in the comparison process. Our findings establish an important causal role of the right FEF in choice, elucidate the underlying mechanism, and provide support for one of the key causal hypotheses associated with the aDDM.
format	article
author	Ian Krajbich Andres Mitsumasu Rafael Polania Christian C Ruff Ernst Fehr
author_facet	Ian Krajbich Andres Mitsumasu Rafael Polania Christian C Ruff Ernst Fehr
author_sort	Ian Krajbich
title	A causal role for the right frontal eye fields in value comparison
title_short	A causal role for the right frontal eye fields in value comparison
title_full	A causal role for the right frontal eye fields in value comparison
title_fullStr	A causal role for the right frontal eye fields in value comparison
title_full_unstemmed	A causal role for the right frontal eye fields in value comparison
title_sort	causal role for the right frontal eye fields in value comparison
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/84f191d477e24f81aba79f74498f5dd3
work_keys_str_mv	AT iankrajbich acausalrolefortherightfrontaleyefieldsinvaluecomparison AT andresmitsumasu acausalrolefortherightfrontaleyefieldsinvaluecomparison AT rafaelpolania acausalrolefortherightfrontaleyefieldsinvaluecomparison AT christiancruff acausalrolefortherightfrontaleyefieldsinvaluecomparison AT ernstfehr acausalrolefortherightfrontaleyefieldsinvaluecomparison AT iankrajbich causalrolefortherightfrontaleyefieldsinvaluecomparison AT andresmitsumasu causalrolefortherightfrontaleyefieldsinvaluecomparison AT rafaelpolania causalrolefortherightfrontaleyefieldsinvaluecomparison AT christiancruff causalrolefortherightfrontaleyefieldsinvaluecomparison AT ernstfehr causalrolefortherightfrontaleyefieldsinvaluecomparison
_version_	1718426912021282816

A causal role for the right frontal eye fields in value comparison

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