TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?

Moahad S Dar,1,2 Sami A Bég3 1Department of Veteran Affairs, Greenville Health Care Center, Greenville, NC, USA; 2Division of Endocrinology & Metabolism, Department of Internal Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA; 3Proactive Living I...

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Autores principales:	Dar MS, Bég SA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Type 2 diabetes macrovascular complications microvascular complications hemoglobin A1C glomerular filtration rate (GFR) TNM cancer staging Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/84f3a2ee9dde4d4e8aa6c2d1866341f7
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spelling	oai:doaj.org-article:84f3a2ee9dde4d4e8aa6c2d1866341f72021-12-02T07:10:46ZTNM cancer staging: can it help develop a novel staging system for type 2 diabetes?1178-7007https://doaj.org/article/84f3a2ee9dde4d4e8aa6c2d1866341f72018-11-01T00:00:00Zhttps://www.dovepress.com/tnm-cancer-staging-can-it-help-develop-a-novel-staging-system-for-type-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Moahad S Dar,1,2 Sami A Bég3 1Department of Veteran Affairs, Greenville Health Care Center, Greenville, NC, USA; 2Division of Endocrinology & Metabolism, Department of Internal Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA; 3Proactive Living Inc., Columbia, SC, USA Abstract: Type 2 diabetes (DM2) constitutes 90%–95% of the diabetes cases and is increasing at an alarming rate in the world. The Centers for Disease Control and Prevention (CDC) estimates that more than 29 million people in the United States have diabetes, which often causes mortality from macrovascular complications and morbidity from microvascular complications. Despite these troubling facts, there is currently no widely accepted staging system for DM2 like there is for cancer. TNM oncologic staging has taken a complex condition like cancer and conveyed likelihood of survival in simple alpha-numeric terms that both patients and providers can understand. Oncology is now entering the era of precision medicine where cancer treatment is increasingly being tailored to each patient’s cancer. In contrast, DM2 lacks a staging system and remains a largely invisible disease even though it kills more Americans and costs more to treat than cancer. Is a comparable staging system for DM2 possible? We propose the Diabetes Staging System for DM2 that utilizes macrovascular events, microvascular complications, estimated glomerular filtration rate (GFR), and hemoglobin A1C to stage DM2. Keywords: type 2 diabetes, macrovascular complications, microvascular complications, hemoglobin A1C, glomerular filtration rate, GFR, TNM cancer stagingDar MSBég SADove Medical PressarticleType 2 diabetesmacrovascular complicationsmicrovascular complicationshemoglobin A1Cglomerular filtration rate (GFR)TNM cancer stagingSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 11, Pp 845-853 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Type 2 diabetes macrovascular complications microvascular complications hemoglobin A1C glomerular filtration rate (GFR) TNM cancer staging Specialties of internal medicine RC581-951
spellingShingle	Type 2 diabetes macrovascular complications microvascular complications hemoglobin A1C glomerular filtration rate (GFR) TNM cancer staging Specialties of internal medicine RC581-951 Dar MS Bég SA TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
description	Moahad S Dar,1,2 Sami A Bég3 1Department of Veteran Affairs, Greenville Health Care Center, Greenville, NC, USA; 2Division of Endocrinology & Metabolism, Department of Internal Medicine, Brody School of Medicine at East Carolina University, Greenville, NC, USA; 3Proactive Living Inc., Columbia, SC, USA Abstract: Type 2 diabetes (DM2) constitutes 90%–95% of the diabetes cases and is increasing at an alarming rate in the world. The Centers for Disease Control and Prevention (CDC) estimates that more than 29 million people in the United States have diabetes, which often causes mortality from macrovascular complications and morbidity from microvascular complications. Despite these troubling facts, there is currently no widely accepted staging system for DM2 like there is for cancer. TNM oncologic staging has taken a complex condition like cancer and conveyed likelihood of survival in simple alpha-numeric terms that both patients and providers can understand. Oncology is now entering the era of precision medicine where cancer treatment is increasingly being tailored to each patient’s cancer. In contrast, DM2 lacks a staging system and remains a largely invisible disease even though it kills more Americans and costs more to treat than cancer. Is a comparable staging system for DM2 possible? We propose the Diabetes Staging System for DM2 that utilizes macrovascular events, microvascular complications, estimated glomerular filtration rate (GFR), and hemoglobin A1C to stage DM2. Keywords: type 2 diabetes, macrovascular complications, microvascular complications, hemoglobin A1C, glomerular filtration rate, GFR, TNM cancer staging
format	article
author	Dar MS Bég SA
author_facet	Dar MS Bég SA
author_sort	Dar MS
title	TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
title_short	TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
title_full	TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
title_fullStr	TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
title_full_unstemmed	TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
title_sort	tnm cancer staging: can it help develop a novel staging system for type 2 diabetes?
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/84f3a2ee9dde4d4e8aa6c2d1866341f7
work_keys_str_mv	AT darms tnmcancerstagingcanithelpdevelopanovelstagingsystemfortype2diabetes AT begsa tnmcancerstagingcanithelpdevelopanovelstagingsystemfortype2diabetes
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TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?

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