Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.

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Autores principales:	Rajeshwer S. Sankhala, Ravi K. Lokareddy, Salma Begum, Ruth A. Pumroy, Richard E. Gillilan, Gino Cingolani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84f5d97d72034197ba5d8d902d0d44a1
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spelling	oai:doaj.org-article:84f5d97d72034197ba5d8d902d0d44a12021-12-02T14:40:59ZThree-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC110.1038/s41467-017-01057-72041-1723https://doaj.org/article/84f5d97d72034197ba5d8d902d0d44a12017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01057-7https://doaj.org/toc/2041-1723Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.Rajeshwer S. SankhalaRavi K. LokareddySalma BegumRuth A. PumroyRichard E. GillilanGino CingolaniNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rajeshwer S. Sankhala Ravi K. Lokareddy Salma Begum Ruth A. Pumroy Richard E. Gillilan Gino Cingolani Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
description	Importin α3 facilitates the nuclear transport of the Ran guanine nucleotide exchange factor RCC1. Here the authors reveal the molecular basis for the selectivity of RCC1 for importin α3 vs the generic importin α1 and discuss the evolution of importin α isoforms.
format	article
author	Rajeshwer S. Sankhala Ravi K. Lokareddy Salma Begum Ruth A. Pumroy Richard E. Gillilan Gino Cingolani
author_facet	Rajeshwer S. Sankhala Ravi K. Lokareddy Salma Begum Ruth A. Pumroy Richard E. Gillilan Gino Cingolani
author_sort	Rajeshwer S. Sankhala
title	Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
title_short	Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
title_full	Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
title_fullStr	Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
title_full_unstemmed	Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
title_sort	three-dimensional context rather than nls amino acid sequence determines importin α subtype specificity for rcc1
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/84f5d97d72034197ba5d8d902d0d44a1
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Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1

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