DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD

Objective: To determine the diagnostic accuracy of Ret-He in detecting IDA, keep ingserum ferritin as goldstandard Study Design: Cross sectional study. Place and Duration of Study: Department of Haematology, AFIP Rawalpindi, from Jan to Jul 2017. Methodology: Study involved 165 female patie...

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Autores principales:	Nabeela Khan, Chaudhry Altaf, Hamid Saeed Malik, Zunera Sajjad, Ayesha Khurshid, Muhammad Tahir Khadim
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	diagnostic accuracy iron deficiency anemia reticulocyte haemoglobin equivalent (ret-he) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/84f63bc46de0419eb5b1119374074f31
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spelling	oai:doaj.org-article:84f63bc46de0419eb5b1119374074f312021-11-09T03:10:16ZDIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD0030-96482411-8842https://doaj.org/article/84f63bc46de0419eb5b1119374074f312019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3404/2379https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To determine the diagnostic accuracy of Ret-He in detecting IDA, keep ingserum ferritin as goldstandard Study Design: Cross sectional study. Place and Duration of Study: Department of Haematology, AFIP Rawalpindi, from Jan to Jul 2017. Methodology: Study involved 165 female patients who presented with anemia (hemoglobin <11g/dl). Ret-He was determined having a level of <27.8 pg/L as diagnostic of IDA. Diagnosis of IDA was confirmed on serum ferritin level <11 ng/ml taking it as gold standard. Accordingly, diagnostic accuracy of Ret-He was determined considering low serum ferritin level as gold standard. Results: The mean age of the patients was 27.52 ± 13.57 years. Mean hemoglobin level was 9.17 ± 1.59 g/dl while mean serum ferritin level was 15.20 ± 12.89 ng/ml. Ret-He ranged from 11.0 pg/L to 39.4 pg/L with a mean of 23.34 ± 8.21 pg/L. IDA on the basis of serum ferritin level was diagnosed in 75 (45.5%) patients while Ret-He labeled IDA in 85 (51.5%) patients. When cross-tabulated, there were 70 TP, 15 FP, 5 FN and 75 TN cases which yielded 93.33% sensitivity, 83.33% specificity, 87.88% accuracy, 82.35% PPV and 93.75% NPV for Ret-He in diagnosing IDA keeping serum ferritin as gold standard. Thus the optimal cut-off value of Ret-He was found to be <27.6 pg/L which gave 93.33% sensitivity and 83.33% specificity in detecting IDA keeping serum ferritin as gold standard. Conclusion: Ret-He was found as fast and reliable technique to diagnose IDA in female population. However, further studies are required for confirmation of its efficacy.Nabeela KhanChaudhry AltafHamid Saeed MalikZunera SajjadAyesha KhurshidMuhammad Tahir KhadimArmy Medical College Rawalpindiarticlediagnostic accuracyiron deficiency anemiareticulocyte haemoglobin equivalent (ret-he)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 1010-1014 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	diagnostic accuracy iron deficiency anemia reticulocyte haemoglobin equivalent (ret-he) Medicine R Medicine (General) R5-920
spellingShingle	diagnostic accuracy iron deficiency anemia reticulocyte haemoglobin equivalent (ret-he) Medicine R Medicine (General) R5-920 Nabeela Khan Chaudhry Altaf Hamid Saeed Malik Zunera Sajjad Ayesha Khurshid Muhammad Tahir Khadim DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD
description	Objective: To determine the diagnostic accuracy of Ret-He in detecting IDA, keep ingserum ferritin as goldstandard Study Design: Cross sectional study. Place and Duration of Study: Department of Haematology, AFIP Rawalpindi, from Jan to Jul 2017. Methodology: Study involved 165 female patients who presented with anemia (hemoglobin <11g/dl). Ret-He was determined having a level of <27.8 pg/L as diagnostic of IDA. Diagnosis of IDA was confirmed on serum ferritin level <11 ng/ml taking it as gold standard. Accordingly, diagnostic accuracy of Ret-He was determined considering low serum ferritin level as gold standard. Results: The mean age of the patients was 27.52 ± 13.57 years. Mean hemoglobin level was 9.17 ± 1.59 g/dl while mean serum ferritin level was 15.20 ± 12.89 ng/ml. Ret-He ranged from 11.0 pg/L to 39.4 pg/L with a mean of 23.34 ± 8.21 pg/L. IDA on the basis of serum ferritin level was diagnosed in 75 (45.5%) patients while Ret-He labeled IDA in 85 (51.5%) patients. When cross-tabulated, there were 70 TP, 15 FP, 5 FN and 75 TN cases which yielded 93.33% sensitivity, 83.33% specificity, 87.88% accuracy, 82.35% PPV and 93.75% NPV for Ret-He in diagnosing IDA keeping serum ferritin as gold standard. Thus the optimal cut-off value of Ret-He was found to be <27.6 pg/L which gave 93.33% sensitivity and 83.33% specificity in detecting IDA keeping serum ferritin as gold standard. Conclusion: Ret-He was found as fast and reliable technique to diagnose IDA in female population. However, further studies are required for confirmation of its efficacy.
format	article
author	Nabeela Khan Chaudhry Altaf Hamid Saeed Malik Zunera Sajjad Ayesha Khurshid Muhammad Tahir Khadim
author_facet	Nabeela Khan Chaudhry Altaf Hamid Saeed Malik Zunera Sajjad Ayesha Khurshid Muhammad Tahir Khadim
author_sort	Nabeela Khan
title	DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD
title_short	DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD
title_full	DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD
title_fullStr	DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD
title_full_unstemmed	DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD
title_sort	diagnostic accuracy of reticulocyte haemoglobin equivalent (rethe) in detecting iron deficiency anaemia keeping serum ferritin as gold standard
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/84f63bc46de0419eb5b1119374074f31
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DIAGNOSTIC ACCURACY OF RETICULOCYTE HAEMOGLOBIN EQUIVALENT (RETHE) IN DETECTING IRON DEFICIENCY ANAEMIA KEEPING SERUM FERRITIN AS GOLD STANDARD

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