Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage

Abstract Systemic oxidative stress is thought to be an important factor in the pathogenesis of glaucoma. In particular, low systemic antioxidative capacity, which normally counters oxidative stress, may contribute to glaucoma. Thus, we investigated the association between biological antioxidant pote...

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Autores principales:	Yoshimi Asano, Noriko Himori, Hiroshi Kunikata, Mai Yamazaki, Yukihiro Shiga, Kazuko Omodaka, Hidetoshi Takahashi, Toru Nakazawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84f65b3f879d4a4ca17a54df427a822e
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spelling	oai:doaj.org-article:84f65b3f879d4a4ca17a54df427a822e2021-12-02T12:32:51ZAge- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage10.1038/s41598-017-08624-42045-2322https://doaj.org/article/84f65b3f879d4a4ca17a54df427a822e2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08624-4https://doaj.org/toc/2045-2322Abstract Systemic oxidative stress is thought to be an important factor in the pathogenesis of glaucoma. In particular, low systemic antioxidative capacity, which normally counters oxidative stress, may contribute to glaucoma. Thus, we investigated the association between biological antioxidant potential (BAP), a biomarker of systemic antioxidative capacity, and glaucoma severity in patients with open-angle glaucoma (OAG). This study included 480 eyes of 240 patients with OAG and 66 healthy control eyes. We measured the BAP serum level with a free radical analyzer and compared it with a weighted estimate of the number of retinal ganglion cells (wrgc), derived from circumpapillary retinal nerve fiber layer thickness and visual field mean deviation. We found that wrgc was uncorrelated with BAP in the overall, male, and female OAG patients, but was correlated in young (aged ≤ 65 years) male OAG patients (better eye: r = 0.33, P = 0.02; worse eye: r = 0.27, P = 0.047). Furthermore, a mixed-effects regression analysis revealed that BAP was an independent contributing factor to wrgc in young male OAG patients (P = 0.02). Thus, systemic antioxidant capacity was associated with glaucomatous damage in relatively young male patients, suggesting that anti-oxidant therapy might be more effective in these patients.Yoshimi AsanoNoriko HimoriHiroshi KunikataMai YamazakiYukihiro ShigaKazuko OmodakaHidetoshi TakahashiToru NakazawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshimi Asano Noriko Himori Hiroshi Kunikata Mai Yamazaki Yukihiro Shiga Kazuko Omodaka Hidetoshi Takahashi Toru Nakazawa Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
description	Abstract Systemic oxidative stress is thought to be an important factor in the pathogenesis of glaucoma. In particular, low systemic antioxidative capacity, which normally counters oxidative stress, may contribute to glaucoma. Thus, we investigated the association between biological antioxidant potential (BAP), a biomarker of systemic antioxidative capacity, and glaucoma severity in patients with open-angle glaucoma (OAG). This study included 480 eyes of 240 patients with OAG and 66 healthy control eyes. We measured the BAP serum level with a free radical analyzer and compared it with a weighted estimate of the number of retinal ganglion cells (wrgc), derived from circumpapillary retinal nerve fiber layer thickness and visual field mean deviation. We found that wrgc was uncorrelated with BAP in the overall, male, and female OAG patients, but was correlated in young (aged ≤ 65 years) male OAG patients (better eye: r = 0.33, P = 0.02; worse eye: r = 0.27, P = 0.047). Furthermore, a mixed-effects regression analysis revealed that BAP was an independent contributing factor to wrgc in young male OAG patients (P = 0.02). Thus, systemic antioxidant capacity was associated with glaucomatous damage in relatively young male patients, suggesting that anti-oxidant therapy might be more effective in these patients.
format	article
author	Yoshimi Asano Noriko Himori Hiroshi Kunikata Mai Yamazaki Yukihiro Shiga Kazuko Omodaka Hidetoshi Takahashi Toru Nakazawa
author_facet	Yoshimi Asano Noriko Himori Hiroshi Kunikata Mai Yamazaki Yukihiro Shiga Kazuko Omodaka Hidetoshi Takahashi Toru Nakazawa
author_sort	Yoshimi Asano
title	Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
title_short	Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
title_full	Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
title_fullStr	Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
title_full_unstemmed	Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
title_sort	age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/84f65b3f879d4a4ca17a54df427a822e
work_keys_str_mv	AT yoshimiasano ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT norikohimori ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT hiroshikunikata ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT maiyamazaki ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT yukihiroshiga ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT kazukoomodaka ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT hidetoshitakahashi ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage AT torunakazawa ageandsexdependencyoftheassociationbetweensystemicantioxidantpotentialandglaucomatousdamage
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Age- and sex-dependency of the association between systemic antioxidant potential and glaucomatous damage

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