Diet and companionship modulate pain via a serotonergic mechanism

Abstract Treatment of severe chronic and acute pain in sickle cell disease (SCD) remains challenging due to the interdependence of pain and psychosocial modulation. We examined whether modulation of the descending pain pathway through an enriched diet and companionship could alleviate pain in transg...

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Autores principales:	Huy Tran, Varun Sagi, Sarita Jarrett, Elise F. Palzer, Rajendra D. Badgaiyan, Kalpna Gupta
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/84f83814df994f77bfca2cd9aef03d4b
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spelling	oai:doaj.org-article:84f83814df994f77bfca2cd9aef03d4b2021-12-02T10:44:15ZDiet and companionship modulate pain via a serotonergic mechanism10.1038/s41598-021-81654-12045-2322https://doaj.org/article/84f83814df994f77bfca2cd9aef03d4b2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81654-1https://doaj.org/toc/2045-2322Abstract Treatment of severe chronic and acute pain in sickle cell disease (SCD) remains challenging due to the interdependence of pain and psychosocial modulation. We examined whether modulation of the descending pain pathway through an enriched diet and companionship could alleviate pain in transgenic sickle mice. Mechanical and thermal hyperalgesia were reduced significantly with enriched diet and/or companionship. Upon withdrawal of both conditions, analgesic effects observed prior to withdrawal were diminished. Serotonin (5-hydroxytryptamine, 5-HT) was found to be increased in the spinal cords of mice provided both treatments. Additionally, 5-HT production improved at the rostral ventromedial medulla and 5-HT accumulated at the dorsal horn of the spinal cord of sickle mice, suggesting the involvement of the descending pain pathway in the analgesic response. Modulation of 5-HT and its effect on hyperalgesia was also investigated through pharmaceutical approaches. Duloxetine, a serotonin-norepinephrine reuptake inhibitor, showed a similar anti-nociceptive effect as the combination of diet and companionship. Depletion of 5-HT through p-chlorophenylalanine attenuated the anti-hyperalgesic effect of enriched diet and companionship. More significantly, improved diet and companionship enhanced the efficacy of a sub-optimal dose of morphine for analgesia in sickle mice. These findings offer the potential to reduce opioid use without pharmacological interventions to develop effective pain management strategies.Huy TranVarun SagiSarita JarrettElise F. PalzerRajendra D. BadgaiyanKalpna GuptaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huy Tran Varun Sagi Sarita Jarrett Elise F. Palzer Rajendra D. Badgaiyan Kalpna Gupta Diet and companionship modulate pain via a serotonergic mechanism
description	Abstract Treatment of severe chronic and acute pain in sickle cell disease (SCD) remains challenging due to the interdependence of pain and psychosocial modulation. We examined whether modulation of the descending pain pathway through an enriched diet and companionship could alleviate pain in transgenic sickle mice. Mechanical and thermal hyperalgesia were reduced significantly with enriched diet and/or companionship. Upon withdrawal of both conditions, analgesic effects observed prior to withdrawal were diminished. Serotonin (5-hydroxytryptamine, 5-HT) was found to be increased in the spinal cords of mice provided both treatments. Additionally, 5-HT production improved at the rostral ventromedial medulla and 5-HT accumulated at the dorsal horn of the spinal cord of sickle mice, suggesting the involvement of the descending pain pathway in the analgesic response. Modulation of 5-HT and its effect on hyperalgesia was also investigated through pharmaceutical approaches. Duloxetine, a serotonin-norepinephrine reuptake inhibitor, showed a similar anti-nociceptive effect as the combination of diet and companionship. Depletion of 5-HT through p-chlorophenylalanine attenuated the anti-hyperalgesic effect of enriched diet and companionship. More significantly, improved diet and companionship enhanced the efficacy of a sub-optimal dose of morphine for analgesia in sickle mice. These findings offer the potential to reduce opioid use without pharmacological interventions to develop effective pain management strategies.
format	article
author	Huy Tran Varun Sagi Sarita Jarrett Elise F. Palzer Rajendra D. Badgaiyan Kalpna Gupta
author_facet	Huy Tran Varun Sagi Sarita Jarrett Elise F. Palzer Rajendra D. Badgaiyan Kalpna Gupta
author_sort	Huy Tran
title	Diet and companionship modulate pain via a serotonergic mechanism
title_short	Diet and companionship modulate pain via a serotonergic mechanism
title_full	Diet and companionship modulate pain via a serotonergic mechanism
title_fullStr	Diet and companionship modulate pain via a serotonergic mechanism
title_full_unstemmed	Diet and companionship modulate pain via a serotonergic mechanism
title_sort	diet and companionship modulate pain via a serotonergic mechanism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84f83814df994f77bfca2cd9aef03d4b
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Diet and companionship modulate pain via a serotonergic mechanism

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