Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL cells, increasing cell-to-cell transcriptional heter...

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Autores principales:	Alessandro Pastore, Federico Gaiti, Sydney X. Lu, Ryan M. Brand, Scott Kulm, Ronan Chaligne, Hongcang Gu, Kevin Y. Huang, Elena K. Stamenova, Wendy Béguelin, Yanwen Jiang, Rafael C. Schulman, Kyu-Tae Kim, Alicia Alonso, John N. Allan, Richard R. Furman, Andreas Gnirke, Catherine J. Wu, Ari M. Melnick, Alexander Meissner, Bradley E. Bernstein, Omar Abdel-Wahab, Dan A. Landau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84f8fc2c23c040aca441459292bfd167
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spelling	oai:doaj.org-article:84f8fc2c23c040aca441459292bfd1672021-12-02T16:58:07ZCorrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL10.1038/s41467-019-09645-52041-1723https://doaj.org/article/84f8fc2c23c040aca441459292bfd1672019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09645-5https://doaj.org/toc/2041-1723In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL cells, increasing cell-to-cell transcriptional heterogeneity.Alessandro PastoreFederico GaitiSydney X. LuRyan M. BrandScott KulmRonan ChaligneHongcang GuKevin Y. HuangElena K. StamenovaWendy BéguelinYanwen JiangRafael C. SchulmanKyu-Tae KimAlicia AlonsoJohn N. AllanRichard R. FurmanAndreas GnirkeCatherine J. WuAri M. MelnickAlexander MeissnerBradley E. BernsteinOmar Abdel-WahabDan A. LandauNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessandro Pastore Federico Gaiti Sydney X. Lu Ryan M. Brand Scott Kulm Ronan Chaligne Hongcang Gu Kevin Y. Huang Elena K. Stamenova Wendy Béguelin Yanwen Jiang Rafael C. Schulman Kyu-Tae Kim Alicia Alonso John N. Allan Richard R. Furman Andreas Gnirke Catherine J. Wu Ari M. Melnick Alexander Meissner Bradley E. Bernstein Omar Abdel-Wahab Dan A. Landau Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
description	In chronic lymphocytic leukemia (CLL), evolution is driven by transcriptional and epigenetic heterogeneity. Here, the authors integrate epigenomic analyses to show how intra-tumoral epigenetic diversity results in divergent chromatin states in CLL cells, increasing cell-to-cell transcriptional heterogeneity.
format	article
author	Alessandro Pastore Federico Gaiti Sydney X. Lu Ryan M. Brand Scott Kulm Ronan Chaligne Hongcang Gu Kevin Y. Huang Elena K. Stamenova Wendy Béguelin Yanwen Jiang Rafael C. Schulman Kyu-Tae Kim Alicia Alonso John N. Allan Richard R. Furman Andreas Gnirke Catherine J. Wu Ari M. Melnick Alexander Meissner Bradley E. Bernstein Omar Abdel-Wahab Dan A. Landau
author_facet	Alessandro Pastore Federico Gaiti Sydney X. Lu Ryan M. Brand Scott Kulm Ronan Chaligne Hongcang Gu Kevin Y. Huang Elena K. Stamenova Wendy Béguelin Yanwen Jiang Rafael C. Schulman Kyu-Tae Kim Alicia Alonso John N. Allan Richard R. Furman Andreas Gnirke Catherine J. Wu Ari M. Melnick Alexander Meissner Bradley E. Bernstein Omar Abdel-Wahab Dan A. Landau
author_sort	Alessandro Pastore
title	Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
title_short	Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
title_full	Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
title_fullStr	Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
title_full_unstemmed	Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
title_sort	corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in cll
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/84f8fc2c23c040aca441459292bfd167
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Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

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