In situ architecture of neuronal α-Synuclein inclusions

In situ architecture of neuronal α-Synuclein inclusions

The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organe...

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Autores principales: Victoria A. Trinkaus, Irene Riera-Tur, Antonio Martínez-Sánchez, Felix J. B. Bäuerlein, Qiang Guo, Thomas Arzberger, Wolfgang Baumeister, Irina Dudanova, Mark S. Hipp, F. Ulrich Hartl, Rubén Fernández-Busnadiego
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff0
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spelling oai:doaj.org-article:84faa4c08a42424bb5304d04db2b7ff02021-12-02T15:51:06ZIn situ architecture of neuronal α-Synuclein inclusions10.1038/s41467-021-22108-02041-1723https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff02021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22108-0https://doaj.org/toc/2041-1723The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organelles without interacting directly.Victoria A. TrinkausIrene Riera-TurAntonio Martínez-SánchezFelix J. B. BäuerleinQiang GuoThomas ArzbergerWolfgang BaumeisterIrina DudanovaMark S. HippF. Ulrich HartlRubén Fernández-BusnadiegoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Victoria A. Trinkaus
Irene Riera-Tur
Antonio Martínez-Sánchez
Felix J. B. Bäuerlein
Qiang Guo
Thomas Arzberger
Wolfgang Baumeister
Irina Dudanova
Mark S. Hipp
F. Ulrich Hartl
Rubén Fernández-Busnadiego
In situ architecture of neuronal α-Synuclein inclusions
description The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organelles without interacting directly.
format article
author Victoria A. Trinkaus
Irene Riera-Tur
Antonio Martínez-Sánchez
Felix J. B. Bäuerlein
Qiang Guo
Thomas Arzberger
Wolfgang Baumeister
Irina Dudanova
Mark S. Hipp
F. Ulrich Hartl
Rubén Fernández-Busnadiego
author_facet Victoria A. Trinkaus
Irene Riera-Tur
Antonio Martínez-Sánchez
Felix J. B. Bäuerlein
Qiang Guo
Thomas Arzberger
Wolfgang Baumeister
Irina Dudanova
Mark S. Hipp
F. Ulrich Hartl
Rubén Fernández-Busnadiego
author_sort Victoria A. Trinkaus
title In situ architecture of neuronal α-Synuclein inclusions
title_short In situ architecture of neuronal α-Synuclein inclusions
title_full In situ architecture of neuronal α-Synuclein inclusions
title_fullStr In situ architecture of neuronal α-Synuclein inclusions
title_full_unstemmed In situ architecture of neuronal α-Synuclein inclusions
title_sort in situ architecture of neuronal α-synuclein inclusions
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff0
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