In situ architecture of neuronal α-Synuclein inclusions
The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organe...
Guardado en:
Autores principales: | Victoria A. Trinkaus, Irene Riera-Tur, Antonio Martínez-Sánchez, Felix J. B. Bäuerlein, Qiang Guo, Thomas Arzberger, Wolfgang Baumeister, Irina Dudanova, Mark S. Hipp, F. Ulrich Hartl, Rubén Fernández-Busnadiego |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff0 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model
por: Patricia Yuste-Checa, et al.
Publicado: (2021) -
Non-uniform self-assembly: On the anisotropic architecture of α-synuclein supra-fibrillar aggregates
por: Slav A. Semerdzhiev, et al.
Publicado: (2017) -
In situ architecture of the algal nuclear pore complex
por: Shyamal Mosalaganti, et al.
Publicado: (2018) -
Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synuclein.
por: Simon M L Paine, et al.
Publicado: (2013) -
Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein
por: Trevor Tyson, et al.
Publicado: (2017)