In situ architecture of neuronal α-Synuclein inclusions

In situ architecture of neuronal α-Synuclein inclusions

The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organe...

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Main Authors: Victoria A. Trinkaus, Irene Riera-Tur, Antonio Martínez-Sánchez, Felix J. B. Bäuerlein, Qiang Guo, Thomas Arzberger, Wolfgang Baumeister, Irina Dudanova, Mark S. Hipp, F. Ulrich Hartl, Rubén Fernández-Busnadiego
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff0
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https://doaj.org/article/84faa4c08a42424bb5304d04db2b7ff0

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