Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil

In the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). Here, the authors show that Drosophila EG are polarized cells that form an internal diffusion barrier. EG cell polarity requires βHeavy-Spec...

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Autores principales:	Nicole Pogodalla, Holger Kranenburg, Simone Rey, Silke Rodrigues, Albert Cardona, Christian Klämbt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84fcc40bb7aa433c9ea9394660da7944
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id	oai:doaj.org-article:84fcc40bb7aa433c9ea9394660da7944
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spelling	oai:doaj.org-article:84fcc40bb7aa433c9ea9394660da79442021-11-08T11:05:40ZDrosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil10.1038/s41467-021-26462-x2041-1723https://doaj.org/article/84fcc40bb7aa433c9ea9394660da79442021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26462-xhttps://doaj.org/toc/2041-1723In the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). Here, the authors show that Drosophila EG are polarized cells that form an internal diffusion barrier. EG cell polarity requires βHeavy-Spectrin and is needed for normal locomotor behaviour.Nicole PogodallaHolger KranenburgSimone ReySilke RodriguesAlbert CardonaChristian KlämbtNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicole Pogodalla Holger Kranenburg Simone Rey Silke Rodrigues Albert Cardona Christian Klämbt Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
description	In the invertebrate CNS, synapses and dendrites are clustered in distinct neuropil areas that are separated from neuronal cell bodies by ensheathing glia (EG). Here, the authors show that Drosophila EG are polarized cells that form an internal diffusion barrier. EG cell polarity requires βHeavy-Spectrin and is needed for normal locomotor behaviour.
format	article
author	Nicole Pogodalla Holger Kranenburg Simone Rey Silke Rodrigues Albert Cardona Christian Klämbt
author_facet	Nicole Pogodalla Holger Kranenburg Simone Rey Silke Rodrigues Albert Cardona Christian Klämbt
author_sort	Nicole Pogodalla
title	Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
title_short	Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
title_full	Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
title_fullStr	Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
title_full_unstemmed	Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
title_sort	drosophila ßheavy-spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/84fcc40bb7aa433c9ea9394660da7944
work_keys_str_mv	AT nicolepogodalla drosophilaßheavyspectrinisrequiredinpolarizedensheathinggliathatformadiffusionbarrieraroundtheneuropil AT holgerkranenburg drosophilaßheavyspectrinisrequiredinpolarizedensheathinggliathatformadiffusionbarrieraroundtheneuropil AT simonerey drosophilaßheavyspectrinisrequiredinpolarizedensheathinggliathatformadiffusionbarrieraroundtheneuropil AT silkerodrigues drosophilaßheavyspectrinisrequiredinpolarizedensheathinggliathatformadiffusionbarrieraroundtheneuropil AT albertcardona drosophilaßheavyspectrinisrequiredinpolarizedensheathinggliathatformadiffusionbarrieraroundtheneuropil AT christianklambt drosophilaßheavyspectrinisrequiredinpolarizedensheathinggliathatformadiffusionbarrieraroundtheneuropil
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Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil

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