Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies

Abstract. Fendiyanto MH, Satrio RD, Widana IDKK, Pratami MP, Nikmah IA, Darmadi D. 2021. Differential hierarchical metabolites expression of red/white Salacca sumatrana Arillus and its molecular docking studies. Biodiversitas 22: 1014-1024. Salak Sidempuan (Salacca sumatrana) is one of the medicinal...

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Autores principales:	Miftahul Huda Fendiyanto, Rizky Dwi Satrio, I Dewa Ketut Kerta Widana, Mentari Putri Pratami, Isna Arofatun Nikmah, Didi Darmadi
Formato:	article
Lenguaje:	EN
Publicado:	MBI & UNS Solo 2021
Materias:	arillus, differential metabolites expression, metabolomics, preventive-antiviral Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/8502729fcb6e4af084d8fe1f77f0e583
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spelling	oai:doaj.org-article:8502729fcb6e4af084d8fe1f77f0e5832021-11-22T00:54:56ZDifferential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies1412-033X2085-472210.13057/biodiv/d220258https://doaj.org/article/8502729fcb6e4af084d8fe1f77f0e5832021-01-01T00:00:00Zhttps://smujo.id/biodiv/article/view/7456https://doaj.org/toc/1412-033Xhttps://doaj.org/toc/2085-4722Abstract. Fendiyanto MH, Satrio RD, Widana IDKK, Pratami MP, Nikmah IA, Darmadi D. 2021. Differential hierarchical metabolites expression of red/white Salacca sumatrana Arillus and its molecular docking studies. Biodiversitas 22: 1014-1024. Salak Sidempuan (Salacca sumatrana) is one of the medicinal plants originating from tropical countries. However, there is very little research on the study of finding bioactive compounds in S. sumatrana using the metabolomic approach. Here, we use two population types of S. sumatrana, e.g., fruit with red and white arillus. We extracted the compounds from the two tissues using the GC-MS technique and further analyzed their antiviral potential using an in-silico molecular docking technique. Fold change analysis showed that in white arillus there were 21 upregulated compounds and 25 downregulated compounds. Metabolites that have high expression in white arillus tissue are ranxinic acid, nicotinic alcohol, stearic acid, 2-furan carboxaldehyde, and others. Six accessions from S. sumatrana based on PCA analysis and separate dendrogram according to the type of arillus, i.e., red and white arillus. Two compounds that act as antivirals found in this study are stearic acid and palmitic acid based on preliminary molecular docking studies. These two compounds could be used for further studies as a preventive measure against SARS-Cov-2 in the future, however, it needs further comprehensive and clinical analysis the future. In conclusion, metabolites in white arillus were distinctly different from red arillus of Snake fruits. In addition, studies on differential metabolite expression on two types of arillus (red/white) can be used as markers in identifying arillus color early by plant breeders.Miftahul Huda FendiyantoRizky Dwi SatrioI Dewa Ketut Kerta WidanaMentari Putri PratamiIsna Arofatun NikmahDidi DarmadiMBI & UNS Soloarticlearillus, differential metabolites expression, metabolomics, preventive-antiviralBiology (General)QH301-705.5ENBiodiversitas, Vol 22, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	arillus, differential metabolites expression, metabolomics, preventive-antiviral Biology (General) QH301-705.5
spellingShingle	arillus, differential metabolites expression, metabolomics, preventive-antiviral Biology (General) QH301-705.5 Miftahul Huda Fendiyanto Rizky Dwi Satrio I Dewa Ketut Kerta Widana Mentari Putri Pratami Isna Arofatun Nikmah Didi Darmadi Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies
description	Abstract. Fendiyanto MH, Satrio RD, Widana IDKK, Pratami MP, Nikmah IA, Darmadi D. 2021. Differential hierarchical metabolites expression of red/white Salacca sumatrana Arillus and its molecular docking studies. Biodiversitas 22: 1014-1024. Salak Sidempuan (Salacca sumatrana) is one of the medicinal plants originating from tropical countries. However, there is very little research on the study of finding bioactive compounds in S. sumatrana using the metabolomic approach. Here, we use two population types of S. sumatrana, e.g., fruit with red and white arillus. We extracted the compounds from the two tissues using the GC-MS technique and further analyzed their antiviral potential using an in-silico molecular docking technique. Fold change analysis showed that in white arillus there were 21 upregulated compounds and 25 downregulated compounds. Metabolites that have high expression in white arillus tissue are ranxinic acid, nicotinic alcohol, stearic acid, 2-furan carboxaldehyde, and others. Six accessions from S. sumatrana based on PCA analysis and separate dendrogram according to the type of arillus, i.e., red and white arillus. Two compounds that act as antivirals found in this study are stearic acid and palmitic acid based on preliminary molecular docking studies. These two compounds could be used for further studies as a preventive measure against SARS-Cov-2 in the future, however, it needs further comprehensive and clinical analysis the future. In conclusion, metabolites in white arillus were distinctly different from red arillus of Snake fruits. In addition, studies on differential metabolite expression on two types of arillus (red/white) can be used as markers in identifying arillus color early by plant breeders.
format	article
author	Miftahul Huda Fendiyanto Rizky Dwi Satrio I Dewa Ketut Kerta Widana Mentari Putri Pratami Isna Arofatun Nikmah Didi Darmadi
author_facet	Miftahul Huda Fendiyanto Rizky Dwi Satrio I Dewa Ketut Kerta Widana Mentari Putri Pratami Isna Arofatun Nikmah Didi Darmadi
author_sort	Miftahul Huda Fendiyanto
title	Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies
title_short	Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies
title_full	Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies
title_fullStr	Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies
title_full_unstemmed	Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies
title_sort	differential hierarchical metabolites expression of red/white salacca sumatrana arillus and its molecular docking studies
publisher	MBI & UNS Solo
publishDate	2021
url	https://doaj.org/article/8502729fcb6e4af084d8fe1f77f0e583
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Differential hierarchical metabolites expression of red/white Salacca sumatrana arillus and its molecular docking studies

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