Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

Whether skeletal muscle fibre gene expression is coordinated as a whole in different nuclei in the fibre is unclear. Here, the authors use single nucleus RNAseq and ATACseq to show the transcriptome heterogeneity of muscle nuclei in the adult mouse fibre, with correlations between the two datasets.

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Autores principales:	Matthieu Dos Santos, Stéphanie Backer, Benjamin Saintpierre, Brigitte Izac, Muriel Andrieu, Franck Letourneur, Frederic Relaix, Athanassia Sotiropoulos, Pascal Maire
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8503a3a7129146fea7a01f6be4dfc5d6
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spelling	oai:doaj.org-article:8503a3a7129146fea7a01f6be4dfc5d62021-12-02T18:37:17ZSingle-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers10.1038/s41467-020-18789-82041-1723https://doaj.org/article/8503a3a7129146fea7a01f6be4dfc5d62020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18789-8https://doaj.org/toc/2041-1723Whether skeletal muscle fibre gene expression is coordinated as a whole in different nuclei in the fibre is unclear. Here, the authors use single nucleus RNAseq and ATACseq to show the transcriptome heterogeneity of muscle nuclei in the adult mouse fibre, with correlations between the two datasets.Matthieu Dos SantosStéphanie BackerBenjamin SaintpierreBrigitte IzacMuriel AndrieuFranck LetourneurFrederic RelaixAthanassia SotiropoulosPascal MaireNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matthieu Dos Santos Stéphanie Backer Benjamin Saintpierre Brigitte Izac Muriel Andrieu Franck Letourneur Frederic Relaix Athanassia Sotiropoulos Pascal Maire Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
description	Whether skeletal muscle fibre gene expression is coordinated as a whole in different nuclei in the fibre is unclear. Here, the authors use single nucleus RNAseq and ATACseq to show the transcriptome heterogeneity of muscle nuclei in the adult mouse fibre, with correlations between the two datasets.
format	article
author	Matthieu Dos Santos Stéphanie Backer Benjamin Saintpierre Brigitte Izac Muriel Andrieu Franck Letourneur Frederic Relaix Athanassia Sotiropoulos Pascal Maire
author_facet	Matthieu Dos Santos Stéphanie Backer Benjamin Saintpierre Brigitte Izac Muriel Andrieu Franck Letourneur Frederic Relaix Athanassia Sotiropoulos Pascal Maire
author_sort	Matthieu Dos Santos
title	Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
title_short	Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
title_full	Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
title_fullStr	Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
title_full_unstemmed	Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
title_sort	single-nucleus rna-seq and fish identify coordinated transcriptional activity in mammalian myofibers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8503a3a7129146fea7a01f6be4dfc5d6
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Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

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