Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

Whether skeletal muscle fibre gene expression is coordinated as a whole in different nuclei in the fibre is unclear. Here, the authors use single nucleus RNAseq and ATACseq to show the transcriptome heterogeneity of muscle nuclei in the adult mouse fibre, with correlations between the two datasets.

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Autores principales: Matthieu Dos Santos, Stéphanie Backer, Benjamin Saintpierre, Brigitte Izac, Muriel Andrieu, Franck Letourneur, Frederic Relaix, Athanassia Sotiropoulos, Pascal Maire
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/8503a3a7129146fea7a01f6be4dfc5d6
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