Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly

While aging is typically associated with cognitive decline, some individuals are able to diverge from the characteristic downward slope and maintain very high levels of cognitive performance. Prior studies have found that cortical thickness in the cingulate cortex, a region involved in information p...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elena Nicole Dominguez, Shauna M. Stark, Yueqi Ren, Maria M. Corrada, Claudia H. Kawas, Craig E. L. Stark
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cortical thickness cingulate cortex top cognitive performer successful aging SuperAger oldest-old Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/850a8153ecc8448b90688cb69a2d6012
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:850a8153ecc8448b90688cb69a2d6012
record_format	dspace
spelling	oai:doaj.org-article:850a8153ecc8448b90688cb69a2d60122021-11-04T07:04:57ZRegional Cortical Thickness Predicts Top Cognitive Performance in the Elderly1663-436510.3389/fnagi.2021.751375https://doaj.org/article/850a8153ecc8448b90688cb69a2d60122021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.751375/fullhttps://doaj.org/toc/1663-4365While aging is typically associated with cognitive decline, some individuals are able to diverge from the characteristic downward slope and maintain very high levels of cognitive performance. Prior studies have found that cortical thickness in the cingulate cortex, a region involved in information processing, memory, and attention, distinguish those with exceptional cognitive abilities when compared to their cognitively more typical elderly peers. Others major areas outside of the cingulate, such as the prefrontal cortex and insula, are also key in successful aging well into late age, suggesting that structural properties across a wide range of areas may better explain differences in cognitive abilities. Here, we aim to assess the role of regional cortical thickness, both in the cingulate and the whole brain, in modeling Top Cognitive Performance (TCP), measured by performance in the top 50th percentile of memory and executive function. Using data from National Alzheimer’s Coordinating Center and The 90 + Study, we examined healthy subjects aged 70–100 years old. We found that, while thickness in cingulate regions can model TCP status with some degree of accuracy, a whole-brain, network-level approach out-performed the localist, cingulate models. These findings suggests a need for more network-style approaches and furthers our understanding of neurobiological factors contributing to preserved cognition.Elena Nicole DominguezShauna M. StarkYueqi RenMaria M. CorradaMaria M. CorradaClaudia H. KawasClaudia H. KawasCraig E. L. StarkCraig E. L. StarkFrontiers Media S.A.articlecortical thicknesscingulate cortextop cognitive performersuccessful agingSuperAgeroldest-oldNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cortical thickness cingulate cortex top cognitive performer successful aging SuperAger oldest-old Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	cortical thickness cingulate cortex top cognitive performer successful aging SuperAger oldest-old Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Elena Nicole Dominguez Shauna M. Stark Yueqi Ren Maria M. Corrada Maria M. Corrada Claudia H. Kawas Claudia H. Kawas Craig E. L. Stark Craig E. L. Stark Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly
description	While aging is typically associated with cognitive decline, some individuals are able to diverge from the characteristic downward slope and maintain very high levels of cognitive performance. Prior studies have found that cortical thickness in the cingulate cortex, a region involved in information processing, memory, and attention, distinguish those with exceptional cognitive abilities when compared to their cognitively more typical elderly peers. Others major areas outside of the cingulate, such as the prefrontal cortex and insula, are also key in successful aging well into late age, suggesting that structural properties across a wide range of areas may better explain differences in cognitive abilities. Here, we aim to assess the role of regional cortical thickness, both in the cingulate and the whole brain, in modeling Top Cognitive Performance (TCP), measured by performance in the top 50th percentile of memory and executive function. Using data from National Alzheimer’s Coordinating Center and The 90 + Study, we examined healthy subjects aged 70–100 years old. We found that, while thickness in cingulate regions can model TCP status with some degree of accuracy, a whole-brain, network-level approach out-performed the localist, cingulate models. These findings suggests a need for more network-style approaches and furthers our understanding of neurobiological factors contributing to preserved cognition.
format	article
author	Elena Nicole Dominguez Shauna M. Stark Yueqi Ren Maria M. Corrada Maria M. Corrada Claudia H. Kawas Claudia H. Kawas Craig E. L. Stark Craig E. L. Stark
author_facet	Elena Nicole Dominguez Shauna M. Stark Yueqi Ren Maria M. Corrada Maria M. Corrada Claudia H. Kawas Claudia H. Kawas Craig E. L. Stark Craig E. L. Stark
author_sort	Elena Nicole Dominguez
title	Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly
title_short	Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly
title_full	Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly
title_fullStr	Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly
title_full_unstemmed	Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly
title_sort	regional cortical thickness predicts top cognitive performance in the elderly
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/850a8153ecc8448b90688cb69a2d6012
work_keys_str_mv	AT elenanicoledominguez regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT shaunamstark regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT yueqiren regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT mariamcorrada regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT mariamcorrada regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT claudiahkawas regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT claudiahkawas regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT craigelstark regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly AT craigelstark regionalcorticalthicknesspredictstopcognitiveperformanceintheelderly
_version_	1718445033832579072

Regional Cortical Thickness Predicts Top Cognitive Performance in the Elderly

Ejemplares similares