C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tools, and define a role of CNHEJ factor XLF in repair...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/850cf4aec291433da8ab79aea3811444 |
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| Sumario: | Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tools, and define a role of CNHEJ factor XLF in repair. |
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