C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tools, and define a role of CNHEJ factor XLF in repair...

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Autores principales:	Ragini Bhargava, Manbir Sandhu, Sanychen Muk, Gabriella Lee, Nagarajan Vaidehi, Jeremy M. Stark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/850cf4aec291433da8ab79aea3811444
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spelling	oai:doaj.org-article:850cf4aec291433da8ab79aea38114442021-12-02T14:40:43ZC-NHEJ without indels is robust and requires synergistic function of distinct XLF domains10.1038/s41467-018-04867-52041-1723https://doaj.org/article/850cf4aec291433da8ab79aea38114442018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04867-5https://doaj.org/toc/2041-1723Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tools, and define a role of CNHEJ factor XLF in repair.Ragini BhargavaManbir SandhuSanychen MukGabriella LeeNagarajan VaidehiJeremy M. StarkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ragini Bhargava Manbir Sandhu Sanychen Muk Gabriella Lee Nagarajan Vaidehi Jeremy M. Stark C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
description	Many factors are involved in end joining (EJ) repair of double strand breaks. Here the authors present a method to identify a chromosomal break repair event that requires classical non homologues end joining (C-NHEJ) using Cas9-based end joining tools, and define a role of CNHEJ factor XLF in repair.
format	article
author	Ragini Bhargava Manbir Sandhu Sanychen Muk Gabriella Lee Nagarajan Vaidehi Jeremy M. Stark
author_facet	Ragini Bhargava Manbir Sandhu Sanychen Muk Gabriella Lee Nagarajan Vaidehi Jeremy M. Stark
author_sort	Ragini Bhargava
title	C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
title_short	C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
title_full	C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
title_fullStr	C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
title_full_unstemmed	C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains
title_sort	c-nhej without indels is robust and requires synergistic function of distinct xlf domains
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/850cf4aec291433da8ab79aea3811444
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C-NHEJ without indels is robust and requires synergistic function of distinct XLF domains

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