Microfluidic Overhauser DNP chip for signal-enhanced compact NMR

Abstract Nuclear magnetic resonance at low field strength is an insensitive spectroscopic technique, precluding portable applications with small sample volumes, such as needed for biomarker detection in body fluids. Here we report a compact double resonant chip stack system that implements in situ d...

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Autores principales:	Sebastian Z. Kiss, Neil MacKinnon, Jan G. Korvink
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/850e01522aef47549e8b9c0e3cd1cab1
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spelling	oai:doaj.org-article:850e01522aef47549e8b9c0e3cd1cab12021-12-02T15:53:59ZMicrofluidic Overhauser DNP chip for signal-enhanced compact NMR10.1038/s41598-021-83625-y2045-2322https://doaj.org/article/850e01522aef47549e8b9c0e3cd1cab12021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83625-yhttps://doaj.org/toc/2045-2322Abstract Nuclear magnetic resonance at low field strength is an insensitive spectroscopic technique, precluding portable applications with small sample volumes, such as needed for biomarker detection in body fluids. Here we report a compact double resonant chip stack system that implements in situ dynamic nuclear polarisation of a 130 nL sample volume, achieving signal enhancements of up to − 60 w.r.t. the thermal equilibrium level at a microwave power level of 0.5 W. This work overcomes instrumental barriers to the use of NMR detection for point-of-care applications.Sebastian Z. KissNeil MacKinnonJan G. KorvinkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sebastian Z. Kiss Neil MacKinnon Jan G. Korvink Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
description	Abstract Nuclear magnetic resonance at low field strength is an insensitive spectroscopic technique, precluding portable applications with small sample volumes, such as needed for biomarker detection in body fluids. Here we report a compact double resonant chip stack system that implements in situ dynamic nuclear polarisation of a 130 nL sample volume, achieving signal enhancements of up to − 60 w.r.t. the thermal equilibrium level at a microwave power level of 0.5 W. This work overcomes instrumental barriers to the use of NMR detection for point-of-care applications.
format	article
author	Sebastian Z. Kiss Neil MacKinnon Jan G. Korvink
author_facet	Sebastian Z. Kiss Neil MacKinnon Jan G. Korvink
author_sort	Sebastian Z. Kiss
title	Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
title_short	Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
title_full	Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
title_fullStr	Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
title_full_unstemmed	Microfluidic Overhauser DNP chip for signal-enhanced compact NMR
title_sort	microfluidic overhauser dnp chip for signal-enhanced compact nmr
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/850e01522aef47549e8b9c0e3cd1cab1
work_keys_str_mv	AT sebastianzkiss microfluidicoverhauserdnpchipforsignalenhancedcompactnmr AT neilmackinnon microfluidicoverhauserdnpchipforsignalenhancedcompactnmr AT jangkorvink microfluidicoverhauserdnpchipforsignalenhancedcompactnmr
_version_	1718385459104579584

Microfluidic Overhauser DNP chip for signal-enhanced compact NMR

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