Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients

Sawsan I Khdair, Yazun B Jarrar, Wassan Jarrar Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, JordanCorrespondence: Sawsan I KhdairDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, JordanTel +962795513275Email...

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Autores principales:	Khdair SI, Jarrar YB, Jarrar W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	jordan diabetes single nucleotide polymorphism vitamin d receptor genetic predisposition. Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/850e0e2d0ad446f9b03fa7054de86615
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spelling	oai:doaj.org-article:850e0e2d0ad446f9b03fa7054de866152021-12-02T17:44:33ZImmunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients1178-7007https://doaj.org/article/850e0e2d0ad446f9b03fa7054de866152021-09-01T00:00:00Zhttps://www.dovepress.com/immunogenetic-prediction-of-vdr-gene-snps-lack-of-association-with-sus-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Sawsan I Khdair, Yazun B Jarrar, Wassan Jarrar Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, JordanCorrespondence: Sawsan I KhdairDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, JordanTel +962795513275Email sawsan.khdair@zuj.edu.joPurpose: The interaction of Vitamin D and its receptor plays a crucial role in immune modulation. Therefore, the relationship between the pathogenesis of type 1 diabetes and the genetic variants of Vitamin D receptor, which is involved in the activity of Vitamin D, was studied extensively in different populations. The association of Vitamin D receptor gene polymorphisms with predisposition to type 1 diabetes revealed controversial and inconclusive results. The aim of this study was to examine the association of four Vitamin D receptor polymorphisms with type 1 diabetes in Jordanian patients.Patients and Methods: Analysis of the single nucleotide polymorphisms FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236) and BsmI (rs1544410) in 100 Jordanian volunteers (50 control and 50 Type 1 diabetes patients) was performed using the highly specific New Generation Sequencing technology.Results: The distribution of allele, genotype as well as haplotype frequencies exhibited no significant (P > 0.05) differences between type 1 diabetes patients and controls. Furthermore, no differences (P > 0.05) in the frequency of the genotypes of the Vitamin D receptor genetic variants were found in relation to the age of disease onset.Conclusion: These findings suggest these four single nucleotide polymorphisms of the Vitamin D receptor gene seem not to be associated with type 1 diabetes predisposition in Jordanian patients. Further wide genome studies are recommended to detect other genetic variant associations with type 1 diabetes among Jordanians.Keywords: jordan, diabetes, single nucleotide polymorphism, vitamin D receptor, genetic predispositionKhdair SIJarrar YBJarrar WDove Medical Pressarticlejordandiabetessingle nucleotide polymorphismvitamin d receptorgenetic predisposition.Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 4079-4087 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	jordan diabetes single nucleotide polymorphism vitamin d receptor genetic predisposition. Specialties of internal medicine RC581-951
spellingShingle	jordan diabetes single nucleotide polymorphism vitamin d receptor genetic predisposition. Specialties of internal medicine RC581-951 Khdair SI Jarrar YB Jarrar W Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients
description	Sawsan I Khdair, Yazun B Jarrar, Wassan Jarrar Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, JordanCorrespondence: Sawsan I KhdairDepartment of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, JordanTel +962795513275Email sawsan.khdair@zuj.edu.joPurpose: The interaction of Vitamin D and its receptor plays a crucial role in immune modulation. Therefore, the relationship between the pathogenesis of type 1 diabetes and the genetic variants of Vitamin D receptor, which is involved in the activity of Vitamin D, was studied extensively in different populations. The association of Vitamin D receptor gene polymorphisms with predisposition to type 1 diabetes revealed controversial and inconclusive results. The aim of this study was to examine the association of four Vitamin D receptor polymorphisms with type 1 diabetes in Jordanian patients.Patients and Methods: Analysis of the single nucleotide polymorphisms FokI (rs2228570), ApaI (rs7975232), TaqI (rs731236) and BsmI (rs1544410) in 100 Jordanian volunteers (50 control and 50 Type 1 diabetes patients) was performed using the highly specific New Generation Sequencing technology.Results: The distribution of allele, genotype as well as haplotype frequencies exhibited no significant (P > 0.05) differences between type 1 diabetes patients and controls. Furthermore, no differences (P > 0.05) in the frequency of the genotypes of the Vitamin D receptor genetic variants were found in relation to the age of disease onset.Conclusion: These findings suggest these four single nucleotide polymorphisms of the Vitamin D receptor gene seem not to be associated with type 1 diabetes predisposition in Jordanian patients. Further wide genome studies are recommended to detect other genetic variant associations with type 1 diabetes among Jordanians.Keywords: jordan, diabetes, single nucleotide polymorphism, vitamin D receptor, genetic predisposition
format	article
author	Khdair SI Jarrar YB Jarrar W
author_facet	Khdair SI Jarrar YB Jarrar W
author_sort	Khdair SI
title	Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients
title_short	Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients
title_full	Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients
title_fullStr	Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients
title_full_unstemmed	Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients
title_sort	immunogenetic prediction of vdr gene snps: lack of association with susceptibility to type 1 diabetes in jordanian patients
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/850e0e2d0ad446f9b03fa7054de86615
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Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients

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