Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)

Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further...

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Autores principales:	Khatami Fatemeh, Mohammadamoli Mahsa, Tavangar Seyed Mohammad
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2018
Materias:	pheochromocytoma paraganglioma genetic epigenetic methylation Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/850f599683ee401bad1d6bed45d10353
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spelling	oai:doaj.org-article:850f599683ee401bad1d6bed45d103532021-12-02T17:49:32ZGenetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)1336-032910.2478/enr-2018-0006https://doaj.org/article/850f599683ee401bad1d6bed45d103532018-01-01T00:00:00Zhttps://doi.org/10.2478/enr-2018-0006https://doaj.org/toc/1336-0329Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues. Accordingly, there is an extreme need for new diagnostic marker(s) to identify tumors with malignant prospective. Th e aim of this study was to review all suggested genetic and epigenetic alterations that are remarkably different between benign and malignant PPGLs. It seems that more than two genetic mutation clusters in PPGLs and other genetic and methylation biomarkers could be targeted for malignancy discrimination in different studies.Khatami FatemehMohammadamoli MahsaTavangar Seyed MohammadSciendoarticlepheochromocytomaparagangliomageneticepigeneticmethylationDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENEndocrine Regulations, Vol 52, Iss 1, Pp 41-54 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	pheochromocytoma paraganglioma genetic epigenetic methylation Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	pheochromocytoma paraganglioma genetic epigenetic methylation Diseases of the endocrine glands. Clinical endocrinology RC648-665 Khatami Fatemeh Mohammadamoli Mahsa Tavangar Seyed Mohammad Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)
description	Pheochromocytomas and paragangliomas (PPGLs) are tumors arising from the adrenal medulla and sympathetic/parasympathetic paraganglia, respectively. According to Th e Cancer Genome Atlas (TCGA), approximately 40% of PPGLs are due to germ line mutations in one of 16 susceptibility genes, and a further 30% are due to somatic alterations in at least seven main genes (VHL, EPAS1, CSDE1, MAX, HRAS, NF1, RET, and possibly KIF1B). Th e diagnosis of malignant PPGL was straight forward in most cases as it was defined as presence of PPGL in non-chromaffin tissues. Accordingly, there is an extreme need for new diagnostic marker(s) to identify tumors with malignant prospective. Th e aim of this study was to review all suggested genetic and epigenetic alterations that are remarkably different between benign and malignant PPGLs. It seems that more than two genetic mutation clusters in PPGLs and other genetic and methylation biomarkers could be targeted for malignancy discrimination in different studies.
format	article
author	Khatami Fatemeh Mohammadamoli Mahsa Tavangar Seyed Mohammad
author_facet	Khatami Fatemeh Mohammadamoli Mahsa Tavangar Seyed Mohammad
author_sort	Khatami Fatemeh
title	Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)
title_short	Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)
title_full	Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)
title_fullStr	Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)
title_full_unstemmed	Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)
title_sort	genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (ppgls)
publisher	Sciendo
publishDate	2018
url	https://doaj.org/article/850f599683ee401bad1d6bed45d10353
work_keys_str_mv	AT khatamifatemeh geneticandepigeneticdifferencesofbenignandmalignantpheochromocytomasandparagangliomasppgls AT mohammadamolimahsa geneticandepigeneticdifferencesofbenignandmalignantpheochromocytomasandparagangliomasppgls AT tavangarseyedmohammad geneticandepigeneticdifferencesofbenignandmalignantpheochromocytomasandparagangliomasppgls
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Genetic and epigenetic differences of benign and malignant pheochromocytomas and paragangliomas (PPGLs)

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