Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo
Shurui Zhao,1 Ze Li,1 Fei Huang,2 Jianhui Wu,1 Lin Gui,1 Xiaoyi Zhang,1 Yaonan Wang,1 Xiaozhen Wang,1 Shiqi Peng,1 Ming Zhao11Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laborato...
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Dove Medical Press
2019
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oai:doaj.org-article:85114a0eab1b48b094592acb131ac7192021-12-02T06:23:55ZNano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo1178-2013https://doaj.org/article/85114a0eab1b48b094592acb131ac7192019-07-01T00:00:00Zhttps://www.dovepress.com/nano-scaled-mtca-kkv-for-targeting-thrombus-releasing-pharmacophores-i-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Shurui Zhao,1 Ze Li,1 Fei Huang,2 Jianhui Wu,1 Lin Gui,1 Xiaoyi Zhang,1 Yaonan Wang,1 Xiaozhen Wang,1 Shiqi Peng,1 Ming Zhao11Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People’s Republic of China; 2Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of ChinaBackground: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine.Methods: MTCA-KKV was characterized by nano-feature, anti-thrombotic activity, thrombolytic activity, thrombus target and targeting release.Results: In vivo 0.01 μmol/kg of MTCA-KKV formed nano-particles less than 100 nm in diameter, targeted thrombus, released anti-thrombotic and thrombolytic pharmacophores, prevented thrombosis and dissolved blood clots.Conclusion: Based on the profiles of targeting thrombus, targeting release, inhibiting thrombosis and dissolving blood clots MTCA-KKV is a promising nano-medicine.Keywords: nano-particles, anti-thrombotic, thrombolytic, targeting, releaseZhao SLi ZHuang FWu JGui LZhang XWang YWang XPeng SZhao MDove Medical Pressarticlenano-particlesanti-thromboticthrombolytictargetingreleaseMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 4817-4831 (2019) |
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DOAJ |
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EN |
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nano-particles anti-thrombotic thrombolytic targeting release Medicine (General) R5-920 |
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nano-particles anti-thrombotic thrombolytic targeting release Medicine (General) R5-920 Zhao S Li Z Huang F Wu J Gui L Zhang X Wang Y Wang X Peng S Zhao M Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| description |
Shurui Zhao,1 Ze Li,1 Fei Huang,2 Jianhui Wu,1 Lin Gui,1 Xiaoyi Zhang,1 Yaonan Wang,1 Xiaozhen Wang,1 Shiqi Peng,1 Ming Zhao11Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, People’s Republic of China; 2Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, People’s Republic of ChinaBackground: In vitro (1R,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxyl-Lys(Pro-Ala-Lys)-Arg-Gly-Asp-Val (MTCA-KKV) adheres activated platelets, targets P-selectin and GPIIb/IIIa. This led to the development of MTCA-KKV as thrombus targeting nano-medicine.Methods: MTCA-KKV was characterized by nano-feature, anti-thrombotic activity, thrombolytic activity, thrombus target and targeting release.Results: In vivo 0.01 μmol/kg of MTCA-KKV formed nano-particles less than 100 nm in diameter, targeted thrombus, released anti-thrombotic and thrombolytic pharmacophores, prevented thrombosis and dissolved blood clots.Conclusion: Based on the profiles of targeting thrombus, targeting release, inhibiting thrombosis and dissolving blood clots MTCA-KKV is a promising nano-medicine.Keywords: nano-particles, anti-thrombotic, thrombolytic, targeting, release |
| format |
article |
| author |
Zhao S Li Z Huang F Wu J Gui L Zhang X Wang Y Wang X Peng S Zhao M |
| author_facet |
Zhao S Li Z Huang F Wu J Gui L Zhang X Wang Y Wang X Peng S Zhao M |
| author_sort |
Zhao S |
| title |
Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| title_short |
Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| title_full |
Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| title_fullStr |
Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| title_full_unstemmed |
Nano-scaled MTCA-KKV: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| title_sort |
nano-scaled mtca-kkv: for targeting thrombus, releasing pharmacophores, inhibiting thrombosis and dissolving blood clots in vivo |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/85114a0eab1b48b094592acb131ac719 |
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