Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis

Abstract The functional significance of extracellular Niemann–Pick disease type C2 protein (NPC2) is poorly defined. It is not known whether there is an association between plasma NPC2 and sepsis. Our exploratory, quantitative proteomic analysis showed a significant increase in the level of plasma N...

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Autores principales:	Yu Bai, Shuangyi Yin, Vivian Gbordzor, Yu Guo, Qing Bai, Shuaiwei Wang, Xiangyan Wei, Na Chen, Yijie Zhang, Wei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8511b0523419427d87446d05142429a0
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spelling	oai:doaj.org-article:8511b0523419427d87446d05142429a02021-12-02T17:05:49ZIncrease in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis10.1038/s41598-021-85478-x2045-2322https://doaj.org/article/8511b0523419427d87446d05142429a02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85478-xhttps://doaj.org/toc/2045-2322Abstract The functional significance of extracellular Niemann–Pick disease type C2 protein (NPC2) is poorly defined. It is not known whether there is an association between plasma NPC2 and sepsis. Our exploratory, quantitative proteomic analysis showed a significant increase in the level of plasma NPC2 in moribund sepsis patients. Thus, we subsequently determined NPC2 concentration in plasma from healthy subjects, pneumonia patients and sepsis patients with comorbid pneumonia; and analyzed the association of plasma NPC2 with organ dysfunction and prognosis of sepsis patients. Our data shows that plasma NPC2 concentration was significantly higher in pneumonia and sepsis patients than healthy subjects, and was further increased in sepsis patients when the SOFA score reached 14. In addition, NPC2 concentration was significantly higher in patients that subsequently developed septic shock or died within 30 days. Moreover, NPC2 level showed the strongest association with the degree of renal dysfunction in sepsis patients. In moribund sepsis patients, however, NPC2 had highest correlation coefficient with indicators of coagulation anomaly. Based on these results, we conclude that the increase in plasma NPC2 in sepsis patients is associated with multiple organ failure, possibly results from a deficiency in renal clearance, and may serve as a prognostic marker for sepsis.Yu BaiShuangyi YinVivian GbordzorYu GuoQing BaiShuaiwei WangXiangyan WeiNa ChenYijie ZhangWei LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Bai Shuangyi Yin Vivian Gbordzor Yu Guo Qing Bai Shuaiwei Wang Xiangyan Wei Na Chen Yijie Zhang Wei Li Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis
description	Abstract The functional significance of extracellular Niemann–Pick disease type C2 protein (NPC2) is poorly defined. It is not known whether there is an association between plasma NPC2 and sepsis. Our exploratory, quantitative proteomic analysis showed a significant increase in the level of plasma NPC2 in moribund sepsis patients. Thus, we subsequently determined NPC2 concentration in plasma from healthy subjects, pneumonia patients and sepsis patients with comorbid pneumonia; and analyzed the association of plasma NPC2 with organ dysfunction and prognosis of sepsis patients. Our data shows that plasma NPC2 concentration was significantly higher in pneumonia and sepsis patients than healthy subjects, and was further increased in sepsis patients when the SOFA score reached 14. In addition, NPC2 concentration was significantly higher in patients that subsequently developed septic shock or died within 30 days. Moreover, NPC2 level showed the strongest association with the degree of renal dysfunction in sepsis patients. In moribund sepsis patients, however, NPC2 had highest correlation coefficient with indicators of coagulation anomaly. Based on these results, we conclude that the increase in plasma NPC2 in sepsis patients is associated with multiple organ failure, possibly results from a deficiency in renal clearance, and may serve as a prognostic marker for sepsis.
format	article
author	Yu Bai Shuangyi Yin Vivian Gbordzor Yu Guo Qing Bai Shuaiwei Wang Xiangyan Wei Na Chen Yijie Zhang Wei Li
author_facet	Yu Bai Shuangyi Yin Vivian Gbordzor Yu Guo Qing Bai Shuaiwei Wang Xiangyan Wei Na Chen Yijie Zhang Wei Li
author_sort	Yu Bai
title	Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis
title_short	Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis
title_full	Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis
title_fullStr	Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis
title_full_unstemmed	Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis
title_sort	increase in plasma niemann–pick disease type c2 protein is associated with poor prognosis of sepsis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8511b0523419427d87446d05142429a0
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Increase in plasma Niemann–Pick disease type C2 protein is associated with poor prognosis of sepsis

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