Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.

MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour sup...

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Autores principales:	Xiangyi Kong, Xiaofeng Xu, Yuhua Yan, Feifei Guo, Jian Li, Yali Hu, Huaijun Zhou, Qingying Xun
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85155b81ceda47eeacd18e6bbe95efef
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id	oai:doaj.org-article:85155b81ceda47eeacd18e6bbe95efef
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spelling	oai:doaj.org-article:85155b81ceda47eeacd18e6bbe95efef2021-11-18T08:30:03ZEstrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.1932-620310.1371/journal.pone.0090810https://doaj.org/article/85155b81ceda47eeacd18e6bbe95efef2014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24595016/?tool=EBIhttps://doaj.org/toc/1932-6203MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.Xiangyi KongXiaofeng XuYuhua YanFeifei GuoJian LiYali HuHuaijun ZhouQingying XunPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 3, p e90810 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiangyi Kong Xiaofeng Xu Yuhua Yan Feifei Guo Jian Li Yali Hu Huaijun Zhou Qingying Xun Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
description	MicroRNA-30c (miR-30c) has been reported to be a tumour suppressor in endometrial cancer (EC). We demonstrate that miR-30c is down-regulated in EC tissue and is highly expressed in estrogen receptor (ER)-negative HEC-1-B cells. MiR-30c directly inhibits MTA-1 expression and functions as a tumour suppressor via the miR-30c-MTA-1 signalling pathway. Furthermore, miR-30c is decreased upon E2 treatment in both ER-positive Ishikawa and ER-negative HEC-1-B cells. Taken together, our results suggest that miR-30c is an important deregulated miRNA in EC and might serve as a potential biomarker and novel therapeutic target for EC.
format	article
author	Xiangyi Kong Xiaofeng Xu Yuhua Yan Feifei Guo Jian Li Yali Hu Huaijun Zhou Qingying Xun
author_facet	Xiangyi Kong Xiaofeng Xu Yuhua Yan Feifei Guo Jian Li Yali Hu Huaijun Zhou Qingying Xun
author_sort	Xiangyi Kong
title	Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_short	Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_full	Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_fullStr	Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_full_unstemmed	Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.
title_sort	estrogen regulates the tumour suppressor mirna-30c and its target gene, mta-1, in endometrial cancer.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/85155b81ceda47eeacd18e6bbe95efef
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Estrogen regulates the tumour suppressor MiRNA-30c and its target gene, MTA-1, in endometrial cancer.

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