A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction

Methods for eQTL mapping from total and allele-specific gene expression typically are too computationally heavy to apply to large scale studies. Here, the authors describe a computationally efficient method to identify eQTLs, fine-map and predict expression from total and allele-specific gene expres...

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Auteurs principaux: Yanyu Liang, François Aguet, Alvaro N. Barbeira, Kristin Ardlie, Hae Kyung Im
Format: article
Langue:EN
Publié: Nature Portfolio 2021
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Accès en ligne:https://doaj.org/article/851a2e4e25024f928fc9e3810b60b5e9
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Résumé:Methods for eQTL mapping from total and allele-specific gene expression typically are too computationally heavy to apply to large scale studies. Here, the authors describe a computationally efficient method to identify eQTLs, fine-map and predict expression from total and allele-specific gene expression