A scalable unified framework of total and allele-specific counts for cis-QTL, fine-mapping, and prediction

Methods for eQTL mapping from total and allele-specific gene expression typically are too computationally heavy to apply to large scale studies. Here, the authors describe a computationally efficient method to identify eQTLs, fine-map and predict expression from total and allele-specific gene expres...

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Autores principales: Yanyu Liang, François Aguet, Alvaro N. Barbeira, Kristin Ardlie, Hae Kyung Im
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/851a2e4e25024f928fc9e3810b60b5e9
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Sumario:Methods for eQTL mapping from total and allele-specific gene expression typically are too computationally heavy to apply to large scale studies. Here, the authors describe a computationally efficient method to identify eQTLs, fine-map and predict expression from total and allele-specific gene expression