Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries

St&eacute;phane Roze,1 Hannah Kurth,2 Barnaby Hunt,3 William Valentine,3 R&eacute;mi Marty11HEVA, Lyon, France; 2Ipsen Pharma, Boulogne-Billancourt, France; 3Ossian Health Economics and Communications, Basel, SwitzerlandBackground: Botulinum toxin A injections are indicated for the m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Valentine W, Hunt B, Kurth H, Roze S, Marty R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/851a9fb9d1504871a27f3a92ca10f9fc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:851a9fb9d1504871a27f3a92ca10f9fc
record_format	dspace
spelling	oai:doaj.org-article:851a9fb9d1504871a27f3a92ca10f9fc2021-12-02T03:48:00ZEvaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries1179-1470https://doaj.org/article/851a9fb9d1504871a27f3a92ca10f9fc2012-11-01T00:00:00Zhttp://www.dovepress.com/evaluation-of-the-cost-per-patient-per-injection-of-botulinum-toxin-a--a11557https://doaj.org/toc/1179-1470St&eacute;phane Roze,1 Hannah Kurth,2 Barnaby Hunt,3 William Valentine,3 R&eacute;mi Marty11HEVA, Lyon, France; 2Ipsen Pharma, Boulogne-Billancourt, France; 3Ossian Health Economics and Communications, Basel, SwitzerlandBackground: Botulinum toxin A injections are indicated for the management of movement disorders, including upper limb spasticity. The aim of this study was to compare the cost per patient per injection for two botulinum toxin A preparations in 19 countries.Methods: Doses of botulinum toxin A are expressed in noninterchangeable units (U), ie, Botox&reg; in 100 Allergan units (100 U) and Dysport&reg; in 500 Speywood units (500 U). Recommended dosages were derived from country-specific summaries of product characteristics or prescribing information. Cost analysis was based on official list prices and expressed in 2011 Euros. The cost per patient per injection was calculated using the recommended dosage in upper limb spasticity combined with price per vial in each country.Results: For upper limb spasticity, the recommended dosage for Dysport in the summary of product characteristics is 1000 U per patient, whereas for Botox the recommended dosage when recommendations were made is 300 U. Allowing for different prices per vial in each country, the cost per patient per injection for upper limb spasticity was less for Dysport than for Botox in 18 (95%) of the 19 countries (mean 17% less across countries). The difference was 20% or higher in nearly half (47%) of the countries. Sensitivity analyses considering available &quot;real-world&quot; dosing showed consistent results, with Dysport being less costly than Botox in all 19 countries.Conclusion: Considering costs per patient per injection based on analysis of recommended dosages in the summary of product characteristics, Dysport remains cheaper than Botox in most countries. Thus, when extrapolated to a national level, substantial savings could be realized by using Dysport in the treatment of upper limb spasticity.Keywords: upper limb spasticity, stroke, botulinum toxin, Dysport&reg;, Botox&reg;Valentine WHunt BKurth HRoze SMarty RDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2012, Iss default, Pp 97-101 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Valentine W Hunt B Kurth H Roze S Marty R Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries
description	St&eacute;phane Roze,1 Hannah Kurth,2 Barnaby Hunt,3 William Valentine,3 R&eacute;mi Marty11HEVA, Lyon, France; 2Ipsen Pharma, Boulogne-Billancourt, France; 3Ossian Health Economics and Communications, Basel, SwitzerlandBackground: Botulinum toxin A injections are indicated for the management of movement disorders, including upper limb spasticity. The aim of this study was to compare the cost per patient per injection for two botulinum toxin A preparations in 19 countries.Methods: Doses of botulinum toxin A are expressed in noninterchangeable units (U), ie, Botox&reg; in 100 Allergan units (100 U) and Dysport&reg; in 500 Speywood units (500 U). Recommended dosages were derived from country-specific summaries of product characteristics or prescribing information. Cost analysis was based on official list prices and expressed in 2011 Euros. The cost per patient per injection was calculated using the recommended dosage in upper limb spasticity combined with price per vial in each country.Results: For upper limb spasticity, the recommended dosage for Dysport in the summary of product characteristics is 1000 U per patient, whereas for Botox the recommended dosage when recommendations were made is 300 U. Allowing for different prices per vial in each country, the cost per patient per injection for upper limb spasticity was less for Dysport than for Botox in 18 (95%) of the 19 countries (mean 17% less across countries). The difference was 20% or higher in nearly half (47%) of the countries. Sensitivity analyses considering available &quot;real-world&quot; dosing showed consistent results, with Dysport being less costly than Botox in all 19 countries.Conclusion: Considering costs per patient per injection based on analysis of recommended dosages in the summary of product characteristics, Dysport remains cheaper than Botox in most countries. Thus, when extrapolated to a national level, substantial savings could be realized by using Dysport in the treatment of upper limb spasticity.Keywords: upper limb spasticity, stroke, botulinum toxin, Dysport&reg;, Botox&reg;
format	article
author	Valentine W Hunt B Kurth H Roze S Marty R
author_facet	Valentine W Hunt B Kurth H Roze S Marty R
author_sort	Valentine W
title	Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries
title_short	Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries
title_full	Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries
title_fullStr	Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries
title_full_unstemmed	Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries
title_sort	evaluation of the cost per patient per injection of botulinum toxin a in upper limb spasticity: comparison of two preparations in 19 countries
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/851a9fb9d1504871a27f3a92ca10f9fc
work_keys_str_mv	AT valentinew evaluationofthecostperpatientperinjectionofbotulinumtoxinainupperlimbspasticitycomparisonoftwopreparationsin19countries AT huntb evaluationofthecostperpatientperinjectionofbotulinumtoxinainupperlimbspasticitycomparisonoftwopreparationsin19countries AT kurthh evaluationofthecostperpatientperinjectionofbotulinumtoxinainupperlimbspasticitycomparisonoftwopreparationsin19countries AT rozes evaluationofthecostperpatientperinjectionofbotulinumtoxinainupperlimbspasticitycomparisonoftwopreparationsin19countries AT martyr evaluationofthecostperpatientperinjectionofbotulinumtoxinainupperlimbspasticitycomparisonoftwopreparationsin19countries
_version_	1718401636413472768

Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries

Ejemplares similares