Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:851d08b0cab545c2b42eefe2157d74fa |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:851d08b0cab545c2b42eefe2157d74fa2021-12-02T16:50:57ZInsights into real-time chemical processes in a calcium sensor protein-directed dynamic library10.1038/s41467-019-10627-w2041-1723https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10627-whttps://doaj.org/toc/2041-1723Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.Andrea Canal-MartínJavier SastreMaría José Sánchez-BarrenaAngeles CanalesSara BaldominosNaiara PascualLoreto Martínez-GonzálezDolores MoleroMª Encarnación Fernández-ValleElena SáezPatricia Blanco-GabellaElena Gómez-RubioSonsoles Martín-SantamaríaAlmudena SáizAlicia MansillaF. Javier CañadaJesús Jiménez-BarberoAna MartínezRuth Pérez-FernándezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Andrea Canal-Martín Javier Sastre María José Sánchez-Barrena Angeles Canales Sara Baldominos Naiara Pascual Loreto Martínez-González Dolores Molero Mª Encarnación Fernández-Valle Elena Sáez Patricia Blanco-Gabella Elena Gómez-Rubio Sonsoles Martín-Santamaría Almudena Sáiz Alicia Mansilla F. Javier Cañada Jesús Jiménez-Barbero Ana Martínez Ruth Pérez-Fernández Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| description |
Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction. |
| format |
article |
| author |
Andrea Canal-Martín Javier Sastre María José Sánchez-Barrena Angeles Canales Sara Baldominos Naiara Pascual Loreto Martínez-González Dolores Molero Mª Encarnación Fernández-Valle Elena Sáez Patricia Blanco-Gabella Elena Gómez-Rubio Sonsoles Martín-Santamaría Almudena Sáiz Alicia Mansilla F. Javier Cañada Jesús Jiménez-Barbero Ana Martínez Ruth Pérez-Fernández |
| author_facet |
Andrea Canal-Martín Javier Sastre María José Sánchez-Barrena Angeles Canales Sara Baldominos Naiara Pascual Loreto Martínez-González Dolores Molero Mª Encarnación Fernández-Valle Elena Sáez Patricia Blanco-Gabella Elena Gómez-Rubio Sonsoles Martín-Santamaría Almudena Sáiz Alicia Mansilla F. Javier Cañada Jesús Jiménez-Barbero Ana Martínez Ruth Pérez-Fernández |
| author_sort |
Andrea Canal-Martín |
| title |
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| title_short |
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| title_full |
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| title_fullStr |
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| title_full_unstemmed |
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| title_sort |
insights into real-time chemical processes in a calcium sensor protein-directed dynamic library |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa |
| work_keys_str_mv |
AT andreacanalmartin insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT javiersastre insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT mariajosesanchezbarrena insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT angelescanales insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT sarabaldominos insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT naiarapascual insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT loretomartinezgonzalez insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT doloresmolero insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT maencarnacionfernandezvalle insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT elenasaez insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT patriciablancogabella insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT elenagomezrubio insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT sonsolesmartinsantamaria insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT almudenasaiz insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT aliciamansilla insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT fjaviercanada insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT jesusjimenezbarbero insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT anamartinez insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary AT ruthperezfernandez insightsintorealtimechemicalprocessesinacalciumsensorproteindirecteddynamiclibrary |
| _version_ |
1718382989905231872 |