Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.

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Autores principales: Andrea Canal-Martín, Javier Sastre, María José Sánchez-Barrena, Angeles Canales, Sara Baldominos, Naiara Pascual, Loreto Martínez-González, Dolores Molero, Mª Encarnación Fernández-Valle, Elena Sáez, Patricia Blanco-Gabella, Elena Gómez-Rubio, Sonsoles Martín-Santamaría, Almudena Sáiz, Alicia Mansilla, F. Javier Cañada, Jesús Jiménez-Barbero, Ana Martínez, Ruth Pérez-Fernández
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa
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spelling oai:doaj.org-article:851d08b0cab545c2b42eefe2157d74fa2021-12-02T16:50:57ZInsights into real-time chemical processes in a calcium sensor protein-directed dynamic library10.1038/s41467-019-10627-w2041-1723https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10627-whttps://doaj.org/toc/2041-1723Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.Andrea Canal-MartínJavier SastreMaría José Sánchez-BarrenaAngeles CanalesSara BaldominosNaiara PascualLoreto Martínez-GonzálezDolores MoleroMª Encarnación Fernández-ValleElena SáezPatricia Blanco-GabellaElena Gómez-RubioSonsoles Martín-SantamaríaAlmudena SáizAlicia MansillaF. Javier CañadaJesús Jiménez-BarberoAna MartínezRuth Pérez-FernándezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Andrea Canal-Martín
Javier Sastre
María José Sánchez-Barrena
Angeles Canales
Sara Baldominos
Naiara Pascual
Loreto Martínez-González
Dolores Molero
Mª Encarnación Fernández-Valle
Elena Sáez
Patricia Blanco-Gabella
Elena Gómez-Rubio
Sonsoles Martín-Santamaría
Almudena Sáiz
Alicia Mansilla
F. Javier Cañada
Jesús Jiménez-Barbero
Ana Martínez
Ruth Pérez-Fernández
Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
description Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.
format article
author Andrea Canal-Martín
Javier Sastre
María José Sánchez-Barrena
Angeles Canales
Sara Baldominos
Naiara Pascual
Loreto Martínez-González
Dolores Molero
Mª Encarnación Fernández-Valle
Elena Sáez
Patricia Blanco-Gabella
Elena Gómez-Rubio
Sonsoles Martín-Santamaría
Almudena Sáiz
Alicia Mansilla
F. Javier Cañada
Jesús Jiménez-Barbero
Ana Martínez
Ruth Pérez-Fernández
author_facet Andrea Canal-Martín
Javier Sastre
María José Sánchez-Barrena
Angeles Canales
Sara Baldominos
Naiara Pascual
Loreto Martínez-González
Dolores Molero
Mª Encarnación Fernández-Valle
Elena Sáez
Patricia Blanco-Gabella
Elena Gómez-Rubio
Sonsoles Martín-Santamaría
Almudena Sáiz
Alicia Mansilla
F. Javier Cañada
Jesús Jiménez-Barbero
Ana Martínez
Ruth Pérez-Fernández
author_sort Andrea Canal-Martín
title Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
title_short Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
title_full Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
title_fullStr Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
title_full_unstemmed Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
title_sort insights into real-time chemical processes in a calcium sensor protein-directed dynamic library
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/851d08b0cab545c2b42eefe2157d74fa
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