RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

In development, the switch from pluripotency to differentiation is important but it is often unclear how it is regulated. Here, the authors show that the tumour suppressor RASSF1A mediates this switch by promoting YAP-p73 transcription, which in turn enables differentiation.

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Autores principales:	Angelos Papaspyropoulos, Leanne Bradley, Asmita Thapa, Chuen Yan Leung, Konstantinos Toskas, Delia Koennig, Dafni-Eleftheria Pefani, Cinzia Raso, Claudia Grou, Garth Hamilton, Nikola Vlahov, Anna Grawenda, Syed Haider, Jagat Chauhan, Ludovico Buti, Alexander Kanapin, Xin Lu, Francesca Buffa, Grigory Dianov, Alex von Kriegsheim, David Matallanas, Anastasia Samsonova, Magdalena Zernicka-Goetz, Eric O’Neill
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/851da86c94cb4859a74e3f6c31088f3a
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spelling	oai:doaj.org-article:851da86c94cb4859a74e3f6c31088f3a2021-12-02T14:39:10ZRASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p7310.1038/s41467-017-02786-52041-1723https://doaj.org/article/851da86c94cb4859a74e3f6c31088f3a2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02786-5https://doaj.org/toc/2041-1723In development, the switch from pluripotency to differentiation is important but it is often unclear how it is regulated. Here, the authors show that the tumour suppressor RASSF1A mediates this switch by promoting YAP-p73 transcription, which in turn enables differentiation.Angelos PapaspyropoulosLeanne BradleyAsmita ThapaChuen Yan LeungKonstantinos ToskasDelia KoennigDafni-Eleftheria PefaniCinzia RasoClaudia GrouGarth HamiltonNikola VlahovAnna GrawendaSyed HaiderJagat ChauhanLudovico ButiAlexander KanapinXin LuFrancesca BuffaGrigory DianovAlex von KriegsheimDavid MatallanasAnastasia SamsonovaMagdalena Zernicka-GoetzEric O’NeillNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Angelos Papaspyropoulos Leanne Bradley Asmita Thapa Chuen Yan Leung Konstantinos Toskas Delia Koennig Dafni-Eleftheria Pefani Cinzia Raso Claudia Grou Garth Hamilton Nikola Vlahov Anna Grawenda Syed Haider Jagat Chauhan Ludovico Buti Alexander Kanapin Xin Lu Francesca Buffa Grigory Dianov Alex von Kriegsheim David Matallanas Anastasia Samsonova Magdalena Zernicka-Goetz Eric O’Neill RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
description	In development, the switch from pluripotency to differentiation is important but it is often unclear how it is regulated. Here, the authors show that the tumour suppressor RASSF1A mediates this switch by promoting YAP-p73 transcription, which in turn enables differentiation.
format	article
author	Angelos Papaspyropoulos Leanne Bradley Asmita Thapa Chuen Yan Leung Konstantinos Toskas Delia Koennig Dafni-Eleftheria Pefani Cinzia Raso Claudia Grou Garth Hamilton Nikola Vlahov Anna Grawenda Syed Haider Jagat Chauhan Ludovico Buti Alexander Kanapin Xin Lu Francesca Buffa Grigory Dianov Alex von Kriegsheim David Matallanas Anastasia Samsonova Magdalena Zernicka-Goetz Eric O’Neill
author_facet	Angelos Papaspyropoulos Leanne Bradley Asmita Thapa Chuen Yan Leung Konstantinos Toskas Delia Koennig Dafni-Eleftheria Pefani Cinzia Raso Claudia Grou Garth Hamilton Nikola Vlahov Anna Grawenda Syed Haider Jagat Chauhan Ludovico Buti Alexander Kanapin Xin Lu Francesca Buffa Grigory Dianov Alex von Kriegsheim David Matallanas Anastasia Samsonova Magdalena Zernicka-Goetz Eric O’Neill
author_sort	Angelos Papaspyropoulos
title	RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
title_short	RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
title_full	RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
title_fullStr	RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
title_full_unstemmed	RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
title_sort	rassf1a uncouples wnt from hippo signalling and promotes yap mediated differentiation via p73
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/851da86c94cb4859a74e3f6c31088f3a
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RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73

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