Unexpected Relations of Historical Anthrax Strain

ABSTRACT In 1998, it was claimed that an 80-year-old glass tube intentionally filled with Bacillus anthracis and embedded in a sugar lump as a WWI biological weapon still contained viable spores. Today, genome sequencing of three colonies isolated in 1998 and subjected to phylogenetic analysis surpr...

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Autores principales:	M. H. Antwerpen, J. W. Sahl, D. Birdsell, T. Pearson, M. J. Pearce, C. Redmond, H. Meyer, P. S. Keim
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/851fce70608342449ae681f98c989b2e
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spelling	oai:doaj.org-article:851fce70608342449ae681f98c989b2e2021-11-15T15:51:00ZUnexpected Relations of Historical Anthrax Strain10.1128/mBio.00440-172150-7511https://doaj.org/article/851fce70608342449ae681f98c989b2e2017-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00440-17https://doaj.org/toc/2150-7511ABSTRACT In 1998, it was claimed that an 80-year-old glass tube intentionally filled with Bacillus anthracis and embedded in a sugar lump as a WWI biological weapon still contained viable spores. Today, genome sequencing of three colonies isolated in 1998 and subjected to phylogenetic analysis surprisingly identified a well-known B. anthracis reference strain isolated in the United States in 1981, pointing to accidental laboratory contamination. IMPORTANCE Next-generation sequencing and subsequent phylogenetic analyses are useful and reliable tools for the classification of recent and historical samples. The reliability of sequences obtained and bioinformatic algorithms has increased in recent years, and research has uncovered the identity of a presumed bioweapon agent as a contaminant.M. H. AntwerpenJ. W. SahlD. BirdsellT. PearsonM. J. PearceC. RedmondH. MeyerP. S. KeimAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 8, Iss 2 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 M. H. Antwerpen J. W. Sahl D. Birdsell T. Pearson M. J. Pearce C. Redmond H. Meyer P. S. Keim Unexpected Relations of Historical Anthrax Strain
description	ABSTRACT In 1998, it was claimed that an 80-year-old glass tube intentionally filled with Bacillus anthracis and embedded in a sugar lump as a WWI biological weapon still contained viable spores. Today, genome sequencing of three colonies isolated in 1998 and subjected to phylogenetic analysis surprisingly identified a well-known B. anthracis reference strain isolated in the United States in 1981, pointing to accidental laboratory contamination. IMPORTANCE Next-generation sequencing and subsequent phylogenetic analyses are useful and reliable tools for the classification of recent and historical samples. The reliability of sequences obtained and bioinformatic algorithms has increased in recent years, and research has uncovered the identity of a presumed bioweapon agent as a contaminant.
format	article
author	M. H. Antwerpen J. W. Sahl D. Birdsell T. Pearson M. J. Pearce C. Redmond H. Meyer P. S. Keim
author_facet	M. H. Antwerpen J. W. Sahl D. Birdsell T. Pearson M. J. Pearce C. Redmond H. Meyer P. S. Keim
author_sort	M. H. Antwerpen
title	Unexpected Relations of Historical Anthrax Strain
title_short	Unexpected Relations of Historical Anthrax Strain
title_full	Unexpected Relations of Historical Anthrax Strain
title_fullStr	Unexpected Relations of Historical Anthrax Strain
title_full_unstemmed	Unexpected Relations of Historical Anthrax Strain
title_sort	unexpected relations of historical anthrax strain
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/851fce70608342449ae681f98c989b2e
work_keys_str_mv	AT mhantwerpen unexpectedrelationsofhistoricalanthraxstrain AT jwsahl unexpectedrelationsofhistoricalanthraxstrain AT dbirdsell unexpectedrelationsofhistoricalanthraxstrain AT tpearson unexpectedrelationsofhistoricalanthraxstrain AT mjpearce unexpectedrelationsofhistoricalanthraxstrain AT credmond unexpectedrelationsofhistoricalanthraxstrain AT hmeyer unexpectedrelationsofhistoricalanthraxstrain AT pskeim unexpectedrelationsofhistoricalanthraxstrain
_version_	1718427409868390400

Unexpected Relations of Historical Anthrax Strain

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