Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer

Chih-Wei Chiang,1,2 Er-Yuan Chuang3 1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Bone and Joint Research Center, Department of Orthopedics, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical Un...

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Autores principales:	Chiang CW, Chuang EY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Polypyrrole Photothermal lung cancer therapy Nanomaterial NIR Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/851ff50aafc44732aef2772a96bff72a
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spelling	oai:doaj.org-article:851ff50aafc44732aef2772a96bff72a2021-12-02T11:08:38ZBiofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer1178-2013https://doaj.org/article/851ff50aafc44732aef2772a96bff72a2019-02-01T00:00:00Zhttps://www.dovepress.com/biofunctional-core-shell-polypyrrole-polyethylenimine-nanocomplex-for--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Chih-Wei Chiang,1,2 Er-Yuan Chuang3 1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Bone and Joint Research Center, Department of Orthopedics, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan Background: Polymeric delivery systems have been elucidated over the last few years as an approach of achieving high therapeutic effect to the local site of malignant disease patients who have cancer. Polypyrrole (Ppy) is a potential organic conducting polymer which has long been recognized as a versatile material due to its excellent stability, conductive properties, and great absorbance in the range of near-infrared (NIR). It is tremendously versatile for use in various biomedical fields such as cancer therapy. NIR irradiation-activated treatment platform technologies are now being considered to be novel and exciting options in potential nanomedicine. However, the realistic photothermal use of Ppy-applied nanomaterials is yet in its early phase, and there are a few disadvantages of Ppy, such as its water insolubility. In the clinic, the common approach for treatment of lung cancer is the delivery of therapeutic active substances through intratumoral administration. Nevertheless, the tumor uptake, regional retention, mechanism of treatment, and tissue organ penetration regarding the developed strategy of this nanomaterial with photothermal hyperthermia are important issues for exerting effective cancer therapy. Materials and methods: In this study, we developed a cationic Ppy–polyethylenimine nanocomplex (NC) with photothermal hyperthermia to study its physicochemical characteristics, including size distribution, zeta potential, and transmission electron microscopy, scanning electron microscopy, and Fourier transform infrared morphology. We also examined the cellular uptake effect on lung cancer cells, the photothermal properties, intracellularly generated reactive oxygen species (ROS), and cytotoxicity. Results: The results suggested that this nanocarrier system was able to effectively attach onto lung cancer cells for subsequent endocytosis. The NCs taken up were able to absorb NIR and then converted the NIR light into local hyperthermia with its intracellular photothermal performance to provide local hyperthermic treatment. This regionally generated hyperthermia also induced ROS formation and improved the killing of lung cancer cells as a promising local photothermal therapy. Conclusion: This development of a nanocarrier would bring a novel therapeutic strategy for lung cancer in the future. Keywords: polypyrrole, photothermal, lung cancer therapy, nanomaterial, near-infraredChiang CWChuang EYDove Medical PressarticlePolypyrrolePhotothermallung cancer therapyNanomaterialNIRMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1575-1585 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Polypyrrole Photothermal lung cancer therapy Nanomaterial NIR Medicine (General) R5-920
spellingShingle	Polypyrrole Photothermal lung cancer therapy Nanomaterial NIR Medicine (General) R5-920 Chiang CW Chuang EY Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
description	Chih-Wei Chiang,1,2 Er-Yuan Chuang3 1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Bone and Joint Research Center, Department of Orthopedics, Taipei Medical University Hospital, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Graduate Institute of Biomedical Materials and Tissue Engineering, Taipei Medical University and International Ph.D. Program in Biomedical Engineering College of Biomedical Engineering, Taipei Medical University, Taipei, Taiwan Background: Polymeric delivery systems have been elucidated over the last few years as an approach of achieving high therapeutic effect to the local site of malignant disease patients who have cancer. Polypyrrole (Ppy) is a potential organic conducting polymer which has long been recognized as a versatile material due to its excellent stability, conductive properties, and great absorbance in the range of near-infrared (NIR). It is tremendously versatile for use in various biomedical fields such as cancer therapy. NIR irradiation-activated treatment platform technologies are now being considered to be novel and exciting options in potential nanomedicine. However, the realistic photothermal use of Ppy-applied nanomaterials is yet in its early phase, and there are a few disadvantages of Ppy, such as its water insolubility. In the clinic, the common approach for treatment of lung cancer is the delivery of therapeutic active substances through intratumoral administration. Nevertheless, the tumor uptake, regional retention, mechanism of treatment, and tissue organ penetration regarding the developed strategy of this nanomaterial with photothermal hyperthermia are important issues for exerting effective cancer therapy. Materials and methods: In this study, we developed a cationic Ppy–polyethylenimine nanocomplex (NC) with photothermal hyperthermia to study its physicochemical characteristics, including size distribution, zeta potential, and transmission electron microscopy, scanning electron microscopy, and Fourier transform infrared morphology. We also examined the cellular uptake effect on lung cancer cells, the photothermal properties, intracellularly generated reactive oxygen species (ROS), and cytotoxicity. Results: The results suggested that this nanocarrier system was able to effectively attach onto lung cancer cells for subsequent endocytosis. The NCs taken up were able to absorb NIR and then converted the NIR light into local hyperthermia with its intracellular photothermal performance to provide local hyperthermic treatment. This regionally generated hyperthermia also induced ROS formation and improved the killing of lung cancer cells as a promising local photothermal therapy. Conclusion: This development of a nanocarrier would bring a novel therapeutic strategy for lung cancer in the future. Keywords: polypyrrole, photothermal, lung cancer therapy, nanomaterial, near-infrared
format	article
author	Chiang CW Chuang EY
author_facet	Chiang CW Chuang EY
author_sort	Chiang CW
title	Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
title_short	Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
title_full	Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
title_fullStr	Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
title_full_unstemmed	Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
title_sort	biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/851ff50aafc44732aef2772a96bff72a
work_keys_str_mv	AT chiangcw biofunctionalcoreshellpolypyrrolendashpolyethyleniminenanocomplexforalocallysustainedphotothermalwithreactiveoxygenspeciesenhancedtherapeuticeffectagainstlungcancer AT chuangey biofunctionalcoreshellpolypyrrolendashpolyethyleniminenanocomplexforalocallysustainedphotothermalwithreactiveoxygenspeciesenhancedtherapeuticeffectagainstlungcancer
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Biofunctional core-shell polypyrrole&ndash;polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer

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Biofunctional core-shell polypyrrole–polyethylenimine nanocomplex for a locally sustained photothermal with reactive oxygen species enhanced therapeutic effect against lung cancer