Prepulse inhibition predicts subjective hearing in rats

Abstract Auditory studies in animals benefit from quick and accurate audiometry. The auditory brainstem response (ABR) and prepulse inhibition (PPI) have been widely used for hearing assessment in animals, but how well these assessments predict subjective audiometry still remains unclear. Human stud...

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Autores principales:	Naoki Wake, Kotaro Ishizu, Taiki Abe, Hirokazu Takahashi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85213802ab5548e09765d9271a078d91
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spelling	oai:doaj.org-article:85213802ab5548e09765d9271a078d912021-12-02T18:48:01ZPrepulse inhibition predicts subjective hearing in rats10.1038/s41598-021-98167-62045-2322https://doaj.org/article/85213802ab5548e09765d9271a078d912021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98167-6https://doaj.org/toc/2045-2322Abstract Auditory studies in animals benefit from quick and accurate audiometry. The auditory brainstem response (ABR) and prepulse inhibition (PPI) have been widely used for hearing assessment in animals, but how well these assessments predict subjective audiometry still remains unclear. Human studies suggest that subjective audiometry is consistent with the ABR-based audiogram, not with the PPI-based audiogram, likely due to top-down processing in the cortex that inhibits PPI. Here, we challenged this view in Wistar rats, as rodents exhibit less complexity of cortical activities and thereby less influence of the cerebral cortex on PPI compared to humans. To test our hypothesis, we investigated whether subjective audiometry correlates with ABR- or PPI-based audiograms across the range of audible frequencies in Wistar rats. The subjective audiogram was obtained through pure-tone audiometry based on operant conditioning. Our results demonstrated that both the ABR-based and PPI-based audiograms significantly correlated to the subjective audiogram. We also found that ASR strength was information-rich, and adequate interpolation of this data offered accurate audiometry. Thus, unlike in humans, PPI could be used to predict subjective audibility in rats.Naoki WakeKotaro IshizuTaiki AbeHirokazu TakahashiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoki Wake Kotaro Ishizu Taiki Abe Hirokazu Takahashi Prepulse inhibition predicts subjective hearing in rats
description	Abstract Auditory studies in animals benefit from quick and accurate audiometry. The auditory brainstem response (ABR) and prepulse inhibition (PPI) have been widely used for hearing assessment in animals, but how well these assessments predict subjective audiometry still remains unclear. Human studies suggest that subjective audiometry is consistent with the ABR-based audiogram, not with the PPI-based audiogram, likely due to top-down processing in the cortex that inhibits PPI. Here, we challenged this view in Wistar rats, as rodents exhibit less complexity of cortical activities and thereby less influence of the cerebral cortex on PPI compared to humans. To test our hypothesis, we investigated whether subjective audiometry correlates with ABR- or PPI-based audiograms across the range of audible frequencies in Wistar rats. The subjective audiogram was obtained through pure-tone audiometry based on operant conditioning. Our results demonstrated that both the ABR-based and PPI-based audiograms significantly correlated to the subjective audiogram. We also found that ASR strength was information-rich, and adequate interpolation of this data offered accurate audiometry. Thus, unlike in humans, PPI could be used to predict subjective audibility in rats.
format	article
author	Naoki Wake Kotaro Ishizu Taiki Abe Hirokazu Takahashi
author_facet	Naoki Wake Kotaro Ishizu Taiki Abe Hirokazu Takahashi
author_sort	Naoki Wake
title	Prepulse inhibition predicts subjective hearing in rats
title_short	Prepulse inhibition predicts subjective hearing in rats
title_full	Prepulse inhibition predicts subjective hearing in rats
title_fullStr	Prepulse inhibition predicts subjective hearing in rats
title_full_unstemmed	Prepulse inhibition predicts subjective hearing in rats
title_sort	prepulse inhibition predicts subjective hearing in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/85213802ab5548e09765d9271a078d91
work_keys_str_mv	AT naokiwake prepulseinhibitionpredictssubjectivehearinginrats AT kotaroishizu prepulseinhibitionpredictssubjectivehearinginrats AT taikiabe prepulseinhibitionpredictssubjectivehearinginrats AT hirokazutakahashi prepulseinhibitionpredictssubjectivehearinginrats
_version_	1718377635155804160

Prepulse inhibition predicts subjective hearing in rats

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