microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa recept...
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Nature Portfolio
2021
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oai:doaj.org-article:8523a0051c014923987d8a460a8d8a1f2021-12-02T14:03:51ZmicroRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity10.1038/s41467-021-21107-52041-1723https://doaj.org/article/8523a0051c014923987d8a460a8d8a1f2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21107-5https://doaj.org/toc/2041-1723Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.Takahiro HorieTetsushi NakaoYui MiyasakaTomohiro NishinoShigenobu MatsumuraFumiko NakazekiYuya IdeMasahiro KimuraShuhei TsujiRandolph Ruiz RodriguezToshimitsu WatanabeTomohiro YamasakiSijia XuChiharu OtaniSawa MiyagawaKazuki MatsushitaNaoya SowaAoi OmoriJin TanakaChika NishimuraMasataka NishigaYasuhide KuwabaraOsamu BabaShin WatanabeHitoo NishiYasuhiro NakashimaMarina R. PicciottoHaruhisa InoueDai WatanabeKazuhiro NakamuraTsutomu SasakiTakeshi KimuraKoh OnoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Takahiro Horie Tetsushi Nakao Yui Miyasaka Tomohiro Nishino Shigenobu Matsumura Fumiko Nakazeki Yuya Ide Masahiro Kimura Shuhei Tsuji Randolph Ruiz Rodriguez Toshimitsu Watanabe Tomohiro Yamasaki Sijia Xu Chiharu Otani Sawa Miyagawa Kazuki Matsushita Naoya Sowa Aoi Omori Jin Tanaka Chika Nishimura Masataka Nishiga Yasuhide Kuwabara Osamu Baba Shin Watanabe Hitoo Nishi Yasuhiro Nakashima Marina R. Picciotto Haruhisa Inoue Dai Watanabe Kazuhiro Nakamura Tsutomu Sasaki Takeshi Kimura Koh Ono microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| description |
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits. |
| format |
article |
| author |
Takahiro Horie Tetsushi Nakao Yui Miyasaka Tomohiro Nishino Shigenobu Matsumura Fumiko Nakazeki Yuya Ide Masahiro Kimura Shuhei Tsuji Randolph Ruiz Rodriguez Toshimitsu Watanabe Tomohiro Yamasaki Sijia Xu Chiharu Otani Sawa Miyagawa Kazuki Matsushita Naoya Sowa Aoi Omori Jin Tanaka Chika Nishimura Masataka Nishiga Yasuhide Kuwabara Osamu Baba Shin Watanabe Hitoo Nishi Yasuhiro Nakashima Marina R. Picciotto Haruhisa Inoue Dai Watanabe Kazuhiro Nakamura Tsutomu Sasaki Takeshi Kimura Koh Ono |
| author_facet |
Takahiro Horie Tetsushi Nakao Yui Miyasaka Tomohiro Nishino Shigenobu Matsumura Fumiko Nakazeki Yuya Ide Masahiro Kimura Shuhei Tsuji Randolph Ruiz Rodriguez Toshimitsu Watanabe Tomohiro Yamasaki Sijia Xu Chiharu Otani Sawa Miyagawa Kazuki Matsushita Naoya Sowa Aoi Omori Jin Tanaka Chika Nishimura Masataka Nishiga Yasuhide Kuwabara Osamu Baba Shin Watanabe Hitoo Nishi Yasuhiro Nakashima Marina R. Picciotto Haruhisa Inoue Dai Watanabe Kazuhiro Nakamura Tsutomu Sasaki Takeshi Kimura Koh Ono |
| author_sort |
Takahiro Horie |
| title |
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| title_short |
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| title_full |
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| title_fullStr |
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| title_full_unstemmed |
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| title_sort |
microrna-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8523a0051c014923987d8a460a8d8a1f |
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