Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes

Abstract Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney tra...

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Autores principales:	Jun Gyo Gwon, Jimi Choi, Cheol Woong Jung, Chang Hun Lee, Se Won Oh, Sang-Kyung Jo, Won Yong Cho, Jae Berm Park, Kyu Ha Huh, Han Ro, Seungyeup Han, Jang-Hee Cho, Sik Lee, Jaeseok Yang, Myung-Gyu Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8524989d27014192abbf6217811f3e10
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spelling	oai:doaj.org-article:8524989d27014192abbf6217811f3e102021-12-02T15:23:07ZImpact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes10.1038/s41598-020-80266-52045-2322https://doaj.org/article/8524989d27014192abbf6217811f3e102021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80266-5https://doaj.org/toc/2045-2322Abstract Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney transplantation (KT). A total of 572 patients were enrolled from a multicenter observational cohort (KNOW-KT). Measurement of WHR and BMI was done at pre-KT, first and last visit year after KT, and the changes of these parameters and their effect on the incident CVD were analyzed. During the median follow up period of 32.73 ± 15.26 months, the new onset CVD developed in 31 out of 572 patients. The older age, diabetes mellitus and increase of WHR from pre KT or previous follow up year were found to be independent factors predicting the new onset CVD in these patients. However, baseline BMI, WHR prior to KT did not predict the incident CVD. The new metabolic burden, presented as increase of WHR in KT patients has a critical impact on the development of new onset CVD. Strategies to prevent the metabolic burden after KT might improve cardiovascular outcomes and patient’s survival.Jun Gyo GwonJimi ChoiCheol Woong JungChang Hun LeeSe Won OhSang-Kyung JoWon Yong ChoJae Berm ParkKyu Ha HuhHan RoSeungyeup HanJang-Hee ChoSik LeeJaeseok YangMyung-Gyu KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jun Gyo Gwon Jimi Choi Cheol Woong Jung Chang Hun Lee Se Won Oh Sang-Kyung Jo Won Yong Cho Jae Berm Park Kyu Ha Huh Han Ro Seungyeup Han Jang-Hee Cho Sik Lee Jaeseok Yang Myung-Gyu Kim Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
description	Abstract Recently, waist to hip ratio (WHR) has been reported to be a better indicator of predicting cardiovascular outcomes than body mass index (BMI). We evaluated the effects of pre or post-transplant changes of WHR or BMI on the new onset cardiovascular diseases (CVD) in recipients of kidney transplantation (KT). A total of 572 patients were enrolled from a multicenter observational cohort (KNOW-KT). Measurement of WHR and BMI was done at pre-KT, first and last visit year after KT, and the changes of these parameters and their effect on the incident CVD were analyzed. During the median follow up period of 32.73 ± 15.26 months, the new onset CVD developed in 31 out of 572 patients. The older age, diabetes mellitus and increase of WHR from pre KT or previous follow up year were found to be independent factors predicting the new onset CVD in these patients. However, baseline BMI, WHR prior to KT did not predict the incident CVD. The new metabolic burden, presented as increase of WHR in KT patients has a critical impact on the development of new onset CVD. Strategies to prevent the metabolic burden after KT might improve cardiovascular outcomes and patient’s survival.
format	article
author	Jun Gyo Gwon Jimi Choi Cheol Woong Jung Chang Hun Lee Se Won Oh Sang-Kyung Jo Won Yong Cho Jae Berm Park Kyu Ha Huh Han Ro Seungyeup Han Jang-Hee Cho Sik Lee Jaeseok Yang Myung-Gyu Kim
author_facet	Jun Gyo Gwon Jimi Choi Cheol Woong Jung Chang Hun Lee Se Won Oh Sang-Kyung Jo Won Yong Cho Jae Berm Park Kyu Ha Huh Han Ro Seungyeup Han Jang-Hee Cho Sik Lee Jaeseok Yang Myung-Gyu Kim
author_sort	Jun Gyo Gwon
title	Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
title_short	Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
title_full	Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
title_fullStr	Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
title_full_unstemmed	Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
title_sort	impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8524989d27014192abbf6217811f3e10
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Impact of changes in waist-to-hip ratio after kidney transplantation on cardiovascular outcomes

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