Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives

Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic act...

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Autores principales:	Andreeva-Gateva P., Tchekalarova J., Kamenova K., Strokova-Stoilova M., Chakar S., Hadjiolova R., Angelova V. T., Surcheva Sl.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	melatonin indole derivatives corneal kindling analgesia aryl hydrocarbon receptors kynurenine Medicine R
Acceso en línea:	https://doaj.org/article/852877ab5e974f5bb7a769ba1574c459
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id	oai:doaj.org-article:852877ab5e974f5bb7a769ba1574c459
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spelling	oai:doaj.org-article:852877ab5e974f5bb7a769ba1574c4592021-12-02T17:31:30ZAryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives0324-175010.2478/amb-2021-0004https://doaj.org/article/852877ab5e974f5bb7a769ba1574c4592021-04-01T00:00:00Zhttps://doi.org/10.2478/amb-2021-0004https://doaj.org/toc/0324-1750Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested.Andreeva-Gateva P.Tchekalarova J.Kamenova K.Strokova-Stoilova M.Chakar S.Hadjiolova R.Angelova V. T.Surcheva Sl.Sciendoarticlemelatoninindole derivativescorneal kindlinganalgesiaaryl hydrocarbon receptorskynurenineMedicineRENActa Medica Bulgarica, Vol 48, Iss 1, Pp 25-33 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	melatonin indole derivatives corneal kindling analgesia aryl hydrocarbon receptors kynurenine Medicine R
spellingShingle	melatonin indole derivatives corneal kindling analgesia aryl hydrocarbon receptors kynurenine Medicine R Andreeva-Gateva P. Tchekalarova J. Kamenova K. Strokova-Stoilova M. Chakar S. Hadjiolova R. Angelova V. T. Surcheva Sl. Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
description	Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested.
format	article
author	Andreeva-Gateva P. Tchekalarova J. Kamenova K. Strokova-Stoilova M. Chakar S. Hadjiolova R. Angelova V. T. Surcheva Sl.
author_facet	Andreeva-Gateva P. Tchekalarova J. Kamenova K. Strokova-Stoilova M. Chakar S. Hadjiolova R. Angelova V. T. Surcheva Sl.
author_sort	Andreeva-Gateva P.
title	Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_short	Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_full	Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_fullStr	Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_full_unstemmed	Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives
title_sort	aryl hydrocarbon receptors in indole derivative treated mice: neuropharmacological perspectives
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/852877ab5e974f5bb7a769ba1574c459
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Aryl Hydrocarbon Receptors in Indole Derivative Treated Mice: Neuropharmacological Perspectives

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