Impaired function and delayed regeneration of dendritic cells in COVID-19.

Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients....

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Autores principales:	Elena Winheim, Linus Rinke, Konstantin Lutz, Anna Reischer, Alexandra Leutbecher, Lina Wolfram, Lisa Rausch, Jan Kranich, Paul R Wratil, Johanna E Huber, Dirk Baumjohann, Simon Rothenfusser, Benjamin Schubert, Anne Hilgendorff, Johannes C Hellmuth, Clemens Scherer, Maximilian Muenchhoff, Michael von Bergwelt-Baildon, Konstantin Stark, Tobias Straub, Thomas Brocker, Oliver T Keppler, Marion Subklewe, Anne B Krug
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/852e03dd622546c7b68aaac8583d6fbd
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spelling	oai:doaj.org-article:852e03dd622546c7b68aaac8583d6fbd2021-12-02T19:59:43ZImpaired function and delayed regeneration of dendritic cells in COVID-19.1553-73661553-737410.1371/journal.ppat.1009742https://doaj.org/article/852e03dd622546c7b68aaac8583d6fbd2021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.ppat.1009742https://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage-HLADR+ cells lacking DC markers. Increased frequency of CD163+ CD14+ cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate naïve CD4+ T cells correlated with disease severity. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients.Elena WinheimLinus RinkeKonstantin LutzAnna ReischerAlexandra LeutbecherLina WolframLisa RauschJan KranichPaul R WratilJohanna E HuberDirk BaumjohannSimon RothenfusserBenjamin SchubertAnne HilgendorffJohannes C HellmuthClemens SchererMaximilian MuenchhoffMichael von Bergwelt-BaildonKonstantin StarkTobias StraubThomas BrockerOliver T KepplerMarion SubkleweAnne B KrugPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 17, Iss 10, p e1009742 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Elena Winheim Linus Rinke Konstantin Lutz Anna Reischer Alexandra Leutbecher Lina Wolfram Lisa Rausch Jan Kranich Paul R Wratil Johanna E Huber Dirk Baumjohann Simon Rothenfusser Benjamin Schubert Anne Hilgendorff Johannes C Hellmuth Clemens Scherer Maximilian Muenchhoff Michael von Bergwelt-Baildon Konstantin Stark Tobias Straub Thomas Brocker Oliver T Keppler Marion Subklewe Anne B Krug Impaired function and delayed regeneration of dendritic cells in COVID-19.
description	Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage-HLADR+ cells lacking DC markers. Increased frequency of CD163+ CD14+ cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate naïve CD4+ T cells correlated with disease severity. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients.
format	article
author	Elena Winheim Linus Rinke Konstantin Lutz Anna Reischer Alexandra Leutbecher Lina Wolfram Lisa Rausch Jan Kranich Paul R Wratil Johanna E Huber Dirk Baumjohann Simon Rothenfusser Benjamin Schubert Anne Hilgendorff Johannes C Hellmuth Clemens Scherer Maximilian Muenchhoff Michael von Bergwelt-Baildon Konstantin Stark Tobias Straub Thomas Brocker Oliver T Keppler Marion Subklewe Anne B Krug
author_facet	Elena Winheim Linus Rinke Konstantin Lutz Anna Reischer Alexandra Leutbecher Lina Wolfram Lisa Rausch Jan Kranich Paul R Wratil Johanna E Huber Dirk Baumjohann Simon Rothenfusser Benjamin Schubert Anne Hilgendorff Johannes C Hellmuth Clemens Scherer Maximilian Muenchhoff Michael von Bergwelt-Baildon Konstantin Stark Tobias Straub Thomas Brocker Oliver T Keppler Marion Subklewe Anne B Krug
author_sort	Elena Winheim
title	Impaired function and delayed regeneration of dendritic cells in COVID-19.
title_short	Impaired function and delayed regeneration of dendritic cells in COVID-19.
title_full	Impaired function and delayed regeneration of dendritic cells in COVID-19.
title_fullStr	Impaired function and delayed regeneration of dendritic cells in COVID-19.
title_full_unstemmed	Impaired function and delayed regeneration of dendritic cells in COVID-19.
title_sort	impaired function and delayed regeneration of dendritic cells in covid-19.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/852e03dd622546c7b68aaac8583d6fbd
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Impaired function and delayed regeneration of dendritic cells in COVID-19.

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