COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS

BACKGROUND AND OBJECTIVE: Changes in the copper (Cu) and zinc (Zn) concentrations have been reported previously in ischemic cardiomyopathy (ICMP). Due to controversial results, the aim of this study was to determine the Cu and Zn concentrations of ISCMP and to evaluate the probable role of these ele...

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Autores principales:	E Salehifar, M Shokrzadeh, A Ghaemian, S Ali Akbari
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2008
Materias:	cardiomyopathy ischemic copper zinc Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8530b96469ad44209bb5796c9bd1a4aa
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spelling	oai:doaj.org-article:8530b96469ad44209bb5796c9bd1a4aa2021-11-10T09:07:27ZCOMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS1561-41072251-7170https://doaj.org/article/8530b96469ad44209bb5796c9bd1a4aa2008-06-01T00:00:00Zhttp://jbums.org/article-1-2991-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Changes in the copper (Cu) and zinc (Zn) concentrations have been reported previously in ischemic cardiomyopathy (ICMP). Due to controversial results, the aim of this study was to determine the Cu and Zn concentrations of ISCMP and to evaluate the probable role of these elements in patients with ICMP.METHODS: This case-control study was conducted on 30 ICMP patients and 27 healthy volunteers. ICMP was diagnosed with a history of myocardial infarction and also vascular diseases confirmed by angiography. Exclusion criteria were renal or hepatic insufficiency, alcohol usage and intake of supplements containing Cu or Zn within one week ago. 15 ml of vein blood has been taken from patients and healthy volunteers. Samples were centrifuged, and separated serums were kept at 20 oC. Cu and Zn levels were assayed with atomic absorption spectrophotometry. T-test was used to compare the levels of Cu and Zn between ICMP and normal subjects. FINDINGS: The mean Cu level of ISCMP group (1.5±0.5 mg/Lit) was significantly more than Cu levels of healthy volunteers (1.3±0.2 mg/Lit) (p= 0.048). The mean Zn levels for ISCMP and healthy volunteers were 1.1±0.3 mg/Lit, and 1.1±0.4 mg/Lit, respectively, that no significant difference was seen. CONCLUSION: Considering the results of this study, Cu may have a role in the development of ICMP. Interventions such as administration of Cu chelators to relieve the symptoms or to decrease the progress of ISCMP would need to be examined in large clinical trials. This study indicated that Zn may not have any role in the development of ICMP.E Salehifar,M Shokrzadeh,A GhaemianS Ali AkbariBabol University of Medical SciencesarticlecardiomyopathyischemiccopperzincMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 10, Iss 2, Pp 23-30 (2008)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	cardiomyopathy ischemic copper zinc Medicine R Medicine (General) R5-920
spellingShingle	cardiomyopathy ischemic copper zinc Medicine R Medicine (General) R5-920 E Salehifar, M Shokrzadeh, A Ghaemian S Ali Akbari COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS
description	BACKGROUND AND OBJECTIVE: Changes in the copper (Cu) and zinc (Zn) concentrations have been reported previously in ischemic cardiomyopathy (ICMP). Due to controversial results, the aim of this study was to determine the Cu and Zn concentrations of ISCMP and to evaluate the probable role of these elements in patients with ICMP.METHODS: This case-control study was conducted on 30 ICMP patients and 27 healthy volunteers. ICMP was diagnosed with a history of myocardial infarction and also vascular diseases confirmed by angiography. Exclusion criteria were renal or hepatic insufficiency, alcohol usage and intake of supplements containing Cu or Zn within one week ago. 15 ml of vein blood has been taken from patients and healthy volunteers. Samples were centrifuged, and separated serums were kept at 20 oC. Cu and Zn levels were assayed with atomic absorption spectrophotometry. T-test was used to compare the levels of Cu and Zn between ICMP and normal subjects. FINDINGS: The mean Cu level of ISCMP group (1.5±0.5 mg/Lit) was significantly more than Cu levels of healthy volunteers (1.3±0.2 mg/Lit) (p= 0.048). The mean Zn levels for ISCMP and healthy volunteers were 1.1±0.3 mg/Lit, and 1.1±0.4 mg/Lit, respectively, that no significant difference was seen. CONCLUSION: Considering the results of this study, Cu may have a role in the development of ICMP. Interventions such as administration of Cu chelators to relieve the symptoms or to decrease the progress of ISCMP would need to be examined in large clinical trials. This study indicated that Zn may not have any role in the development of ICMP.
format	article
author	E Salehifar, M Shokrzadeh, A Ghaemian S Ali Akbari
author_facet	E Salehifar, M Shokrzadeh, A Ghaemian S Ali Akbari
author_sort	E Salehifar,
title	COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS
title_short	COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS
title_full	COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS
title_fullStr	COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS
title_full_unstemmed	COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS
title_sort	comparison of copper and zinc levels in the serum of ischemic cardiomyopathy patients with healthy volunteers
publisher	Babol University of Medical Sciences
publishDate	2008
url	https://doaj.org/article/8530b96469ad44209bb5796c9bd1a4aa
work_keys_str_mv	AT esalehifar comparisonofcopperandzinclevelsintheserumofischemiccardiomyopathypatientswithhealthyvolunteers AT mshokrzadeh comparisonofcopperandzinclevelsintheserumofischemiccardiomyopathypatientswithhealthyvolunteers AT aghaemian comparisonofcopperandzinclevelsintheserumofischemiccardiomyopathypatientswithhealthyvolunteers AT saliakbari comparisonofcopperandzinclevelsintheserumofischemiccardiomyopathypatientswithhealthyvolunteers
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COMPARISON OF COPPER AND ZINC LEVELS IN THE SERUM OF ISCHEMIC CARDIOMYOPATHY PATIENTS WITH HEALTHY VOLUNTEERS

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