Sustained high expression of multiple APOBEC3 cytidine deaminases in systemic lupus erythematosus

Abstract APOBEC3 (A3) enzymes are best known for their role as antiviral restriction factors and as mutagens in cancer. Although four of them, A3A, A3B, A3F and A3G, are induced by type-1-interferon (IFN-I), their role in inflammatory conditions is unknown. We thus investigated the expression of A3,...

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Main Authors: Danielle Perez-Bercoff, Hélène Laude, Morgane Lemaire, Oliver Hunewald, Valérie Thiers, Marco Vignuzzi, Hervé Blanc, Aurélie Poli, Zahir Amoura, Vincent Caval, Rodolphe Suspène, François Hafezi, Alexis Mathian, Jean-Pierre Vartanian, Simon Wain-Hobson
Format: article
Language:EN
Published: Nature Portfolio 2021
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R
Q
Online Access:https://doaj.org/article/85323af00c3940d4aadf6ca47ac55360
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