LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

Chondrocytes have altered cellular metabolism in the context of osteoarthritis, but whether and how these changes are associated with inflammation is a controversial area. Here the authors show that inflammatory NF-κB signalling drives a glycolytic shift in chondrocytes and the production of ROS, wh...

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Autores principales:	Manoj Arra, Gaurav Swarnkar, Ke Ke, Jesse E. Otero, Jun Ying, Xin Duan, Takashi Maruyama, Muhammad Farooq Rai, Regis J. O’Keefe, Gabriel Mbalaviele, Jie Shen, Yousef Abu-Amer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85329ba61e30432694e6760ca1cad04a
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spelling	oai:doaj.org-article:85329ba61e30432694e6760ca1cad04a2021-12-02T16:24:53ZLDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis10.1038/s41467-020-17242-02041-1723https://doaj.org/article/85329ba61e30432694e6760ca1cad04a2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17242-0https://doaj.org/toc/2041-1723Chondrocytes have altered cellular metabolism in the context of osteoarthritis, but whether and how these changes are associated with inflammation is a controversial area. Here the authors show that inflammatory NF-κB signalling drives a glycolytic shift in chondrocytes and the production of ROS, which drives cartilage catabolism.Manoj ArraGaurav SwarnkarKe KeJesse E. OteroJun YingXin DuanTakashi MaruyamaMuhammad Farooq RaiRegis J. O’KeefeGabriel MbalavieleJie ShenYousef Abu-AmerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Manoj Arra Gaurav Swarnkar Ke Ke Jesse E. Otero Jun Ying Xin Duan Takashi Maruyama Muhammad Farooq Rai Regis J. O’Keefe Gabriel Mbalaviele Jie Shen Yousef Abu-Amer LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
description	Chondrocytes have altered cellular metabolism in the context of osteoarthritis, but whether and how these changes are associated with inflammation is a controversial area. Here the authors show that inflammatory NF-κB signalling drives a glycolytic shift in chondrocytes and the production of ROS, which drives cartilage catabolism.
format	article
author	Manoj Arra Gaurav Swarnkar Ke Ke Jesse E. Otero Jun Ying Xin Duan Takashi Maruyama Muhammad Farooq Rai Regis J. O’Keefe Gabriel Mbalaviele Jie Shen Yousef Abu-Amer
author_facet	Manoj Arra Gaurav Swarnkar Ke Ke Jesse E. Otero Jun Ying Xin Duan Takashi Maruyama Muhammad Farooq Rai Regis J. O’Keefe Gabriel Mbalaviele Jie Shen Yousef Abu-Amer
author_sort	Manoj Arra
title	LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
title_short	LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
title_full	LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
title_fullStr	LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
title_full_unstemmed	LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
title_sort	ldha-mediated ros generation in chondrocytes is a potential therapeutic target for osteoarthritis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/85329ba61e30432694e6760ca1cad04a
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LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis

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