Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts

Leukoencephalopathy, cerebral calcifications, and cysts (LCC) form a very rare association which is named as “Labrune syndrome” after Labrune who reported the first case in 1996. To the best of our knowledge only eight to 10 cases have been reported in literature to date. We report a case of a 26-ye...

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Autores principales:	Anagha R. Joshi, Kiran Kulkarni, Ankita U. Shah
Formato:	article
Lenguaje:	EN
Publicado:	Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Materias:	labrune syndrome leukoencephalopathy cerebral calcifications cysts Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/8532e86d0a0041849157e4e4778ea696
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spelling	oai:doaj.org-article:8532e86d0a0041849157e4e4778ea6962021-11-13T23:32:31ZLabrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts0971-30261998-380810.1055/s-0041-1736398https://doaj.org/article/8532e86d0a0041849157e4e4778ea6962021-07-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1736398https://doaj.org/toc/0971-3026https://doaj.org/toc/1998-3808Leukoencephalopathy, cerebral calcifications, and cysts (LCC) form a very rare association which is named as “Labrune syndrome” after Labrune who reported the first case in 1996. To the best of our knowledge only eight to 10 cases have been reported in literature to date. We report a case of a 26-year-old male with onset of neurological symptoms in late adolescence (at 19 years of age) and presented with complains of continued seizures for 7 years, giddiness with imbalance, and slowly progressive motor symptoms. MRI brain revealed multiple calcifications in bilateral basal ganglia, cerebral white matter, multiple cystic lesions in the supratentorial white matter, and abnormal diffused bilateral white matter T2 hyperintensity suggesting leukoencephalopathy. Histopathological evaluation revealed prominent congested blood vessels suggestive of angiomatous changes and cystic areas suggestive of secondary gliosis.Anagha R. JoshiKiran KulkarniAnkita U. ShahThieme Medical and Scientific Publishers Pvt. Ltd.articlelabrune syndromeleukoencephalopathycerebral calcificationscystsMedical physics. Medical radiology. Nuclear medicineR895-920ENIndian Journal of Radiology and Imaging, Vol 31, Iss 03, Pp 772-775 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	labrune syndrome leukoencephalopathy cerebral calcifications cysts Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	labrune syndrome leukoencephalopathy cerebral calcifications cysts Medical physics. Medical radiology. Nuclear medicine R895-920 Anagha R. Joshi Kiran Kulkarni Ankita U. Shah Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
description	Leukoencephalopathy, cerebral calcifications, and cysts (LCC) form a very rare association which is named as “Labrune syndrome” after Labrune who reported the first case in 1996. To the best of our knowledge only eight to 10 cases have been reported in literature to date. We report a case of a 26-year-old male with onset of neurological symptoms in late adolescence (at 19 years of age) and presented with complains of continued seizures for 7 years, giddiness with imbalance, and slowly progressive motor symptoms. MRI brain revealed multiple calcifications in bilateral basal ganglia, cerebral white matter, multiple cystic lesions in the supratentorial white matter, and abnormal diffused bilateral white matter T2 hyperintensity suggesting leukoencephalopathy. Histopathological evaluation revealed prominent congested blood vessels suggestive of angiomatous changes and cystic areas suggestive of secondary gliosis.
format	article
author	Anagha R. Joshi Kiran Kulkarni Ankita U. Shah
author_facet	Anagha R. Joshi Kiran Kulkarni Ankita U. Shah
author_sort	Anagha R. Joshi
title	Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
title_short	Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
title_full	Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
title_fullStr	Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
title_full_unstemmed	Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts
title_sort	labrune syndrome: a very rare association of leukoencephalopathy, cerebral calcifications, and cysts
publisher	Thieme Medical and Scientific Publishers Pvt. Ltd.
publishDate	2021
url	https://doaj.org/article/8532e86d0a0041849157e4e4778ea696
work_keys_str_mv	AT anagharjoshi labrunesyndromeaveryrareassociationofleukoencephalopathycerebralcalcificationsandcysts AT kirankulkarni labrunesyndromeaveryrareassociationofleukoencephalopathycerebralcalcificationsandcysts AT ankitaushah labrunesyndromeaveryrareassociationofleukoencephalopathycerebralcalcificationsandcysts
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Labrune Syndrome: A Very Rare Association of Leukoencephalopathy, Cerebral Calcifications, and Cysts

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