The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles

Daniel J Cooney1, Anthony J Hickey21Department of Biomedical Engineering; 2School of Pharmacy, University of North Carolina, Chapel Hill, NC, USAAbstract: The influence of diesel exhaust particles (DEP) on the lungs and heart is currently a topic of great interest in inhalation toxicology. Epidemiol...

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Autores principales:	Daniel J Cooney, Anthony J Hickey
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/85351c0928e349ab83462715320f11de
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spelling	oai:doaj.org-article:85351c0928e349ab83462715320f11de2021-12-02T03:05:00ZThe generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles1176-91141178-2013https://doaj.org/article/85351c0928e349ab83462715320f11de2008-08-01T00:00:00Zhttp://www.dovepress.com/the-generation-of-diesel-exhaust-particle-aerosols-from-a-bulk-source--a2019https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Daniel J Cooney1, Anthony J Hickey21Department of Biomedical Engineering; 2School of Pharmacy, University of North Carolina, Chapel Hill, NC, USAAbstract: The influence of diesel exhaust particles (DEP) on the lungs and heart is currently a topic of great interest in inhalation toxicology. Epidemiological data and animal studies have implicated airborne particulate matter and DEP in increased morbidity and mortality due to a number of cardiopulmonary diseases including asthma, chronic obstructive pulmonary disorder, and lung cancer. The pathogeneses of these diseases are being studied using animal models and cell culture techniques. Real-time exposures to freshly combusted diesel fuel are complex and require significant infrastructure including engine operations, dilution air, and monitoring and control of gases. A method of generating DEP aerosols from a bulk source in an aerodynamic size range similar to atmospheric DEP would be a desirable and useful alternative. Metered dose inhaler technology was adopted to generate aerosols from suspensions of DEP in the propellant hydrofluoroalkane 134a. Inertial impaction data indicated that the particle size distributions of the generated aerosols were trimodal, with count median aerodynamic diameters less than 100 nm. Scanning electron microscopy of deposited particles showed tightly aggregated particles, as would be expected from an evaporative process. Chemical analysis indicated that there were no major changes in the mass proportion of 2 specific aromatic hydrocarbons (benzo[a]pyrene and benzo[k]fluoranthene) in the particles resulting from the aerosolization process.Keywords: diesel exhaust particles, aerosol, inhalation toxicology Daniel J CooneyAnthony J HickeyDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2008, Iss Issue 4, Pp 435-449 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Daniel J Cooney Anthony J Hickey The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
description	Daniel J Cooney1, Anthony J Hickey21Department of Biomedical Engineering; 2School of Pharmacy, University of North Carolina, Chapel Hill, NC, USAAbstract: The influence of diesel exhaust particles (DEP) on the lungs and heart is currently a topic of great interest in inhalation toxicology. Epidemiological data and animal studies have implicated airborne particulate matter and DEP in increased morbidity and mortality due to a number of cardiopulmonary diseases including asthma, chronic obstructive pulmonary disorder, and lung cancer. The pathogeneses of these diseases are being studied using animal models and cell culture techniques. Real-time exposures to freshly combusted diesel fuel are complex and require significant infrastructure including engine operations, dilution air, and monitoring and control of gases. A method of generating DEP aerosols from a bulk source in an aerodynamic size range similar to atmospheric DEP would be a desirable and useful alternative. Metered dose inhaler technology was adopted to generate aerosols from suspensions of DEP in the propellant hydrofluoroalkane 134a. Inertial impaction data indicated that the particle size distributions of the generated aerosols were trimodal, with count median aerodynamic diameters less than 100 nm. Scanning electron microscopy of deposited particles showed tightly aggregated particles, as would be expected from an evaporative process. Chemical analysis indicated that there were no major changes in the mass proportion of 2 specific aromatic hydrocarbons (benzo[a]pyrene and benzo[k]fluoranthene) in the particles resulting from the aerosolization process.Keywords: diesel exhaust particles, aerosol, inhalation toxicology
format	article
author	Daniel J Cooney Anthony J Hickey
author_facet	Daniel J Cooney Anthony J Hickey
author_sort	Daniel J Cooney
title	The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
title_short	The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
title_full	The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
title_fullStr	The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
title_full_unstemmed	The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
title_sort	generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/85351c0928e349ab83462715320f11de
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The generation of diesel exhaust particle aerosols from a bulk source in an aerodynamic size range similar to atmospheric particles

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