PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling
Non-alcoholic fatty liver disease (NAFLD) has become a prevalent chronic liver disease, however, drugs to treat this disease are still lacking. Here, the authors show that PPDPF inhibits the development of hepatic steatosis by negatively regulating mTORC1-S6K-SREBP1 signaling, which provides a poten...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8537535d3b06469c9a7a4a00e3cfe23a |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8537535d3b06469c9a7a4a00e3cfe23a |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8537535d3b06469c9a7a4a00e3cfe23a2021-12-02T16:53:16ZPPDPF alleviates hepatic steatosis through inhibition of mTOR signaling10.1038/s41467-021-23285-82041-1723https://doaj.org/article/8537535d3b06469c9a7a4a00e3cfe23a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23285-8https://doaj.org/toc/2041-1723Non-alcoholic fatty liver disease (NAFLD) has become a prevalent chronic liver disease, however, drugs to treat this disease are still lacking. Here, the authors show that PPDPF inhibits the development of hepatic steatosis by negatively regulating mTORC1-S6K-SREBP1 signaling, which provides a potential therapeutic candidate for NAFLD treatment.Ning MaYi-Kang WangSheng XuQian-Zhi NiQian-Wen ZhengBing ZhuHui-Jun CaoHao JiangFeng-Kun ZhangYan-Mei YuanEr-Bin ZhangTian-Wei ChenJi XiaXu-Fen DingZhen-Hua ChenXiu-Ping ZhangKang WangShu-Qun ChengLin QiuZhi-Gang LiYong-Chun YuXiao-Fan WangBin ZhouJing-Jing LiDong XieNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Ning Ma Yi-Kang Wang Sheng Xu Qian-Zhi Ni Qian-Wen Zheng Bing Zhu Hui-Jun Cao Hao Jiang Feng-Kun Zhang Yan-Mei Yuan Er-Bin Zhang Tian-Wei Chen Ji Xia Xu-Fen Ding Zhen-Hua Chen Xiu-Ping Zhang Kang Wang Shu-Qun Cheng Lin Qiu Zhi-Gang Li Yong-Chun Yu Xiao-Fan Wang Bin Zhou Jing-Jing Li Dong Xie PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling |
| description |
Non-alcoholic fatty liver disease (NAFLD) has become a prevalent chronic liver disease, however, drugs to treat this disease are still lacking. Here, the authors show that PPDPF inhibits the development of hepatic steatosis by negatively regulating mTORC1-S6K-SREBP1 signaling, which provides a potential therapeutic candidate for NAFLD treatment. |
| format |
article |
| author |
Ning Ma Yi-Kang Wang Sheng Xu Qian-Zhi Ni Qian-Wen Zheng Bing Zhu Hui-Jun Cao Hao Jiang Feng-Kun Zhang Yan-Mei Yuan Er-Bin Zhang Tian-Wei Chen Ji Xia Xu-Fen Ding Zhen-Hua Chen Xiu-Ping Zhang Kang Wang Shu-Qun Cheng Lin Qiu Zhi-Gang Li Yong-Chun Yu Xiao-Fan Wang Bin Zhou Jing-Jing Li Dong Xie |
| author_facet |
Ning Ma Yi-Kang Wang Sheng Xu Qian-Zhi Ni Qian-Wen Zheng Bing Zhu Hui-Jun Cao Hao Jiang Feng-Kun Zhang Yan-Mei Yuan Er-Bin Zhang Tian-Wei Chen Ji Xia Xu-Fen Ding Zhen-Hua Chen Xiu-Ping Zhang Kang Wang Shu-Qun Cheng Lin Qiu Zhi-Gang Li Yong-Chun Yu Xiao-Fan Wang Bin Zhou Jing-Jing Li Dong Xie |
| author_sort |
Ning Ma |
| title |
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling |
| title_short |
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling |
| title_full |
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling |
| title_fullStr |
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling |
| title_full_unstemmed |
PPDPF alleviates hepatic steatosis through inhibition of mTOR signaling |
| title_sort |
ppdpf alleviates hepatic steatosis through inhibition of mtor signaling |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8537535d3b06469c9a7a4a00e3cfe23a |
| work_keys_str_mv |
AT ningma ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT yikangwang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT shengxu ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT qianzhini ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT qianwenzheng ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT bingzhu ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT huijuncao ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT haojiang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT fengkunzhang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT yanmeiyuan ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT erbinzhang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT tianweichen ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT jixia ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT xufending ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT zhenhuachen ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT xiupingzhang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT kangwang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT shuquncheng ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT linqiu ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT zhigangli ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT yongchunyu ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT xiaofanwang ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT binzhou ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT jingjingli ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling AT dongxie ppdpfalleviateshepaticsteatosisthroughinhibitionofmtorsignaling |
| _version_ |
1718382871019782144 |