The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.

The Drosophila Cadherin Fat (Ft) has been identified as a crucial regulator of tissue size and Planar Cell Polarity (PCP). However, the precise mechanism by which Ft regulates these processes remains unclear. In order to advance our understanding of the action of Ft, we have sought to identify the c...

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Autores principales:	Xuesong Zhao, Chung-Hui Yang, Michael A Simon
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/853a0d5a20e44ff1b49ecc3c57d8f54b
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spelling	oai:doaj.org-article:853a0d5a20e44ff1b49ecc3c57d8f54b2021-11-18T07:46:36ZThe Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.1932-620310.1371/journal.pone.0062998https://doaj.org/article/853a0d5a20e44ff1b49ecc3c57d8f54b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23667559/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The Drosophila Cadherin Fat (Ft) has been identified as a crucial regulator of tissue size and Planar Cell Polarity (PCP). However, the precise mechanism by which Ft regulates these processes remains unclear. In order to advance our understanding of the action of Ft, we have sought to identify the crucial Ft effector domains. Here we report that a small region of the Ft cytoplasmic domain (H2 region) is both necessary and sufficient, when membrane localized, to support viability and prevent tissue overgrowth. Interestingly, the H2 region is dispensable for regulating PCP signaling, whereas the mutant Ft lacking the H2 region is fully capable of directing PCP. This result suggests that Ft's roles in PCP signaling and tissue size control are separable, and each can be carried out independently. Surprisingly, the crucial regions of Ft identified in our structure-function study do not overlap with the previously reported interaction regions with Atrophin, Dco, or Lowfat.Xuesong ZhaoChung-Hui YangMichael A SimonPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e62998 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xuesong Zhao Chung-Hui Yang Michael A Simon The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
description	The Drosophila Cadherin Fat (Ft) has been identified as a crucial regulator of tissue size and Planar Cell Polarity (PCP). However, the precise mechanism by which Ft regulates these processes remains unclear. In order to advance our understanding of the action of Ft, we have sought to identify the crucial Ft effector domains. Here we report that a small region of the Ft cytoplasmic domain (H2 region) is both necessary and sufficient, when membrane localized, to support viability and prevent tissue overgrowth. Interestingly, the H2 region is dispensable for regulating PCP signaling, whereas the mutant Ft lacking the H2 region is fully capable of directing PCP. This result suggests that Ft's roles in PCP signaling and tissue size control are separable, and each can be carried out independently. Surprisingly, the crucial regions of Ft identified in our structure-function study do not overlap with the previously reported interaction regions with Atrophin, Dco, or Lowfat.
format	article
author	Xuesong Zhao Chung-Hui Yang Michael A Simon
author_facet	Xuesong Zhao Chung-Hui Yang Michael A Simon
author_sort	Xuesong Zhao
title	The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
title_short	The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
title_full	The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
title_fullStr	The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
title_full_unstemmed	The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.
title_sort	drosophila cadherin fat regulates tissue size and planar cell polarity through different domains.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/853a0d5a20e44ff1b49ecc3c57d8f54b
work_keys_str_mv	AT xuesongzhao thedrosophilacadherinfatregulatestissuesizeandplanarcellpolaritythroughdifferentdomains AT chunghuiyang thedrosophilacadherinfatregulatestissuesizeandplanarcellpolaritythroughdifferentdomains AT michaelasimon thedrosophilacadherinfatregulatestissuesizeandplanarcellpolaritythroughdifferentdomains AT xuesongzhao drosophilacadherinfatregulatestissuesizeandplanarcellpolaritythroughdifferentdomains AT chunghuiyang drosophilacadherinfatregulatestissuesizeandplanarcellpolaritythroughdifferentdomains AT michaelasimon drosophilacadherinfatregulatestissuesizeandplanarcellpolaritythroughdifferentdomains
_version_	1718422984703606784

The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains.

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