The basis and advances in clinical application of boron neutron capture therapy

Abstract Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. BNCT is based on the nuclea...

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Autores principales:	Huifang He, Jiyuan Li, Ping Jiang, Suqing Tian, Hao Wang, Ruitai Fan, Junqi Liu, Yuyan Yang, Zhibo Liu, Junjie Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Boron neutron capture therapy Boron carriers Neutron source Tumor Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/853b477e10d9446e865768ed6412c549
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spelling	oai:doaj.org-article:853b477e10d9446e865768ed6412c5492021-11-14T12:15:42ZThe basis and advances in clinical application of boron neutron capture therapy10.1186/s13014-021-01939-71748-717Xhttps://doaj.org/article/853b477e10d9446e865768ed6412c5492021-11-01T00:00:00Zhttps://doi.org/10.1186/s13014-021-01939-7https://doaj.org/toc/1748-717XAbstract Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. BNCT is based on the nuclear reaction that occurs when 10B capture low-energy thermal neutrons to yield high-linear energy transfer (LET) α particles and recoiling 7Li nuclei. A large number of 10B atoms have to be localized within the tumor cells for BNCT to be effective, and an adequate number of thermal neutrons need to be absorbed by the 10B atoms to generate lethal 10B (n, α)7Li reactions. Effective boron neutron capture therapy cannot be achieved without appropriate boron carriers. Improvement in boron delivery and the development of the best dosing paradigms for both boronophenylalanine (BPA) and sodium borocaptate (BSH) are of major importance, yet these still have not been optimized. Here, we present a review of this treatment modality from the perspectives of radiation oncology, biology, and physics. This manuscript provides a brief introduction of the mechanism of cancer-cell-selective killing by BNCT, radiobiological factors, and progress in the development of boron carriers and neutron sources as well as the results of clinical study.Huifang HeJiyuan LiPing JiangSuqing TianHao WangRuitai FanJunqi LiuYuyan YangZhibo LiuJunjie WangBMCarticleBoron neutron capture therapyBoron carriersNeutron sourceTumorMedical physics. Medical radiology. Nuclear medicineR895-920Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENRadiation Oncology, Vol 16, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Boron neutron capture therapy Boron carriers Neutron source Tumor Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Boron neutron capture therapy Boron carriers Neutron source Tumor Medical physics. Medical radiology. Nuclear medicine R895-920 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Huifang He Jiyuan Li Ping Jiang Suqing Tian Hao Wang Ruitai Fan Junqi Liu Yuyan Yang Zhibo Liu Junjie Wang The basis and advances in clinical application of boron neutron capture therapy
description	Abstract Boron neutron capture therapy (BNCT) was first proposed as early as 1936, and research on BNCT has progressed relatively slowly but steadily. BNCT is a potentially useful tool for cancer treatment that selectively damages cancer cells while sparing normal tissue. BNCT is based on the nuclear reaction that occurs when 10B capture low-energy thermal neutrons to yield high-linear energy transfer (LET) α particles and recoiling 7Li nuclei. A large number of 10B atoms have to be localized within the tumor cells for BNCT to be effective, and an adequate number of thermal neutrons need to be absorbed by the 10B atoms to generate lethal 10B (n, α)7Li reactions. Effective boron neutron capture therapy cannot be achieved without appropriate boron carriers. Improvement in boron delivery and the development of the best dosing paradigms for both boronophenylalanine (BPA) and sodium borocaptate (BSH) are of major importance, yet these still have not been optimized. Here, we present a review of this treatment modality from the perspectives of radiation oncology, biology, and physics. This manuscript provides a brief introduction of the mechanism of cancer-cell-selective killing by BNCT, radiobiological factors, and progress in the development of boron carriers and neutron sources as well as the results of clinical study.
format	article
author	Huifang He Jiyuan Li Ping Jiang Suqing Tian Hao Wang Ruitai Fan Junqi Liu Yuyan Yang Zhibo Liu Junjie Wang
author_facet	Huifang He Jiyuan Li Ping Jiang Suqing Tian Hao Wang Ruitai Fan Junqi Liu Yuyan Yang Zhibo Liu Junjie Wang
author_sort	Huifang He
title	The basis and advances in clinical application of boron neutron capture therapy
title_short	The basis and advances in clinical application of boron neutron capture therapy
title_full	The basis and advances in clinical application of boron neutron capture therapy
title_fullStr	The basis and advances in clinical application of boron neutron capture therapy
title_full_unstemmed	The basis and advances in clinical application of boron neutron capture therapy
title_sort	basis and advances in clinical application of boron neutron capture therapy
publisher	BMC
publishDate	2021
url	https://doaj.org/article/853b477e10d9446e865768ed6412c549
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The basis and advances in clinical application of boron neutron capture therapy

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