Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia

Identification of Novel Non-secosteroidal Vitamin D Receptor Agonists with Potent Cardioprotective Effects and devoid of Hypercalcemia

Abstract Vitamin D regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect. Using a virtual screening platform to search novel chemical probes that activate the vitamin D signaling, we report discovery of novel non-steroidal small-molecule compounds that...

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Autores principales: Santosh A. Khedkar, Mohammed A. Samad, Sangita Choudhury, Ji Yoo Lee, Dongsheng Zhang, Ravi I. Thadhani, S. Ananth Karumanchi, Alan C. Rigby, Peter M. Kang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/853bea727f7e4295a02ec950760e473a
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