State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review

Abstract Background Intra-articular hip injections for osteoarthritis represent a useful instrument to reduce pain and disability in the common clinical practice. Several medications can be injected locally with different level of evidence-based efficacy. Objective The objective of this systematic r...

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Autores principales:	Paola Emilia Ferrara, Sefora Codazza, Daniele Coraci, Giuseppe Malerba, Giorgio Ferriero, Gianpaolo Ronconi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Intra-articular injections hip osteoarthritis hyaluronic acid corticosteroids platelet-rich plasma Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/85408051822448da8fe00df5768da3dc
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spelling	oai:doaj.org-article:85408051822448da8fe00df5768da3dc2021-12-05T12:18:11ZState of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review10.1186/s12891-021-04866-61471-2474https://doaj.org/article/85408051822448da8fe00df5768da3dc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12891-021-04866-6https://doaj.org/toc/1471-2474Abstract Background Intra-articular hip injections for osteoarthritis represent a useful instrument to reduce pain and disability in the common clinical practice. Several medications can be injected locally with different level of evidence-based efficacy. Objective The objective of this systematic review is to investigate the effectiveness of intra-articular injections of different medications or substances for the pain treatment and the management of disability in subjects affected by hip osteoarthritis. Methods Two reviewers selected independently randomised controlled trials published in the last 10 years, using PubMed and Scopus databases. The risk of bias was evaluated with Cochrane library assessment tool. Results 12 randomised controlled trials have been selected. We found 8 papers comparing hyaluronic acid with platelet rich plasma, with corticosteroids and with saline solution; 1 paper compares two types of hyaluronic acid with different molecular weights; 3 papers study the effects of corticosteroids alone or compared to ketorolac or saline solution. Conclusions The studies reviewed were heterogeneous regarding sample size, level of osteoarthritis, evaluated with Kellegren-Lawrence score, medications used and follow up timings. However, we have observed that intra-articular injections of platelet-rich plasma seem to decrease pain at short term and disability at long term, in patients affected by hip osteoarthritis better than hyaluronic acid. The association of hyaluronic acid and corticosteroids could give better results compared to hyaluronic acid alone, while the use of intra-articular ketorolac and saline solution requires more studies.Paola Emilia FerraraSefora CodazzaDaniele CoraciGiuseppe MalerbaGiorgio FerrieroGianpaolo RonconiBMCarticleIntra-articular injectionshiposteoarthritishyaluronic acidcorticosteroidsplatelet-rich plasmaDiseases of the musculoskeletal systemRC925-935ENBMC Musculoskeletal Disorders, Vol 22, Iss S2, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intra-articular injections hip osteoarthritis hyaluronic acid corticosteroids platelet-rich plasma Diseases of the musculoskeletal system RC925-935
spellingShingle	Intra-articular injections hip osteoarthritis hyaluronic acid corticosteroids platelet-rich plasma Diseases of the musculoskeletal system RC925-935 Paola Emilia Ferrara Sefora Codazza Daniele Coraci Giuseppe Malerba Giorgio Ferriero Gianpaolo Ronconi State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
description	Abstract Background Intra-articular hip injections for osteoarthritis represent a useful instrument to reduce pain and disability in the common clinical practice. Several medications can be injected locally with different level of evidence-based efficacy. Objective The objective of this systematic review is to investigate the effectiveness of intra-articular injections of different medications or substances for the pain treatment and the management of disability in subjects affected by hip osteoarthritis. Methods Two reviewers selected independently randomised controlled trials published in the last 10 years, using PubMed and Scopus databases. The risk of bias was evaluated with Cochrane library assessment tool. Results 12 randomised controlled trials have been selected. We found 8 papers comparing hyaluronic acid with platelet rich plasma, with corticosteroids and with saline solution; 1 paper compares two types of hyaluronic acid with different molecular weights; 3 papers study the effects of corticosteroids alone or compared to ketorolac or saline solution. Conclusions The studies reviewed were heterogeneous regarding sample size, level of osteoarthritis, evaluated with Kellegren-Lawrence score, medications used and follow up timings. However, we have observed that intra-articular injections of platelet-rich plasma seem to decrease pain at short term and disability at long term, in patients affected by hip osteoarthritis better than hyaluronic acid. The association of hyaluronic acid and corticosteroids could give better results compared to hyaluronic acid alone, while the use of intra-articular ketorolac and saline solution requires more studies.
format	article
author	Paola Emilia Ferrara Sefora Codazza Daniele Coraci Giuseppe Malerba Giorgio Ferriero Gianpaolo Ronconi
author_facet	Paola Emilia Ferrara Sefora Codazza Daniele Coraci Giuseppe Malerba Giorgio Ferriero Gianpaolo Ronconi
author_sort	Paola Emilia Ferrara
title	State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
title_short	State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
title_full	State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
title_fullStr	State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
title_full_unstemmed	State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
title_sort	state of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review
publisher	BMC
publishDate	2021
url	https://doaj.org/article/85408051822448da8fe00df5768da3dc
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State of art in intra-articular hip injections of different medications for osteoarthritis: a systematic review

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