Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.

To survive elevated temperatures, ectotherms adjust the fluidity of membranes by fine-tuning lipid desaturation levels in a process previously described to be cell autonomous. We have discovered that, in Caenorhabditis elegans, neuronal heat shock factor 1 (HSF-1), the conserved master regulator of...

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Main Authors:	Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W Wingett, Hermine Kienberger, Karin Kleigrewe, Mario de Bono, Michael J O Wakelam, Olivia Casanueva
Format:	article
Language:	EN
Published:	Public Library of Science (PLoS) 2021
Subjects:	Biology (General) QH301-705.5
Online Access:	https://doaj.org/article/8540a2eb797040a69c7c29bcb73e2db0
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Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans

by Laetitia Chauve, Francesca Hodge, Sharlene Murdoch, Fatemeh Masoudzadeh, Harry-Jack Mann, Andrea F. Lopez-Clavijo, Hanneke Okkenhaug, Greg West, Bebiana C. Sousa, Anne Segonds-Pichon, Cheryl Li, Steven W. Wingett, Hermine Kienberger, Karin Kleigrewe, Mario de Bono, Michael J. O. Wakelam, Olivia Casanueva
Published 2021

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Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.

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