Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling

α-Fluoromethyl arenes are common substructures in pharmaceuticals and agrochemicals but synthetic routes are still rare. Here the authors describe Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diaryl...

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Autores principales:	Masakazu Nambo, Jacky C.-H. Yim, Luiza B. O. Freitas, Yasuyo Tahara, Zachary T. Ariki, Yuuki Maekawa, Daisuke Yokogawa, Cathleen M. Crudden
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85482d2823a043c0b578abf6eb4fb873
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spelling	oai:doaj.org-article:85482d2823a043c0b578abf6eb4fb8732021-12-02T16:57:34ZModular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling10.1038/s41467-019-11758-w2041-1723https://doaj.org/article/85482d2823a043c0b578abf6eb4fb8732019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11758-whttps://doaj.org/toc/2041-1723α-Fluoromethyl arenes are common substructures in pharmaceuticals and agrochemicals but synthetic routes are still rare. Here the authors describe Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes.Masakazu NamboJacky C.-H. YimLuiza B. O. FreitasYasuyo TaharaZachary T. ArikiYuuki MaekawaDaisuke YokogawaCathleen M. CruddenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Masakazu Nambo Jacky C.-H. Yim Luiza B. O. Freitas Yasuyo Tahara Zachary T. Ariki Yuuki Maekawa Daisuke Yokogawa Cathleen M. Crudden Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
description	α-Fluoromethyl arenes are common substructures in pharmaceuticals and agrochemicals but synthetic routes are still rare. Here the authors describe Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes.
format	article
author	Masakazu Nambo Jacky C.-H. Yim Luiza B. O. Freitas Yasuyo Tahara Zachary T. Ariki Yuuki Maekawa Daisuke Yokogawa Cathleen M. Crudden
author_facet	Masakazu Nambo Jacky C.-H. Yim Luiza B. O. Freitas Yasuyo Tahara Zachary T. Ariki Yuuki Maekawa Daisuke Yokogawa Cathleen M. Crudden
author_sort	Masakazu Nambo
title	Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
title_short	Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
title_full	Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
title_fullStr	Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
title_full_unstemmed	Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
title_sort	modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/85482d2823a043c0b578abf6eb4fb873
work_keys_str_mv	AT masakazunambo modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT jackychyim modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT luizabofreitas modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT yasuyotahara modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT zacharytariki modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT yuukimaekawa modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT daisukeyokogawa modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling AT cathleenmcrudden modularsynthesisofafluorinatedarylmethanesviadesulfonylativecrosscoupling
_version_	1718382510712291328

Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling

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