The antimicrobial potential of Streptomyces from insect microbiomes

The antimicrobial potential of Streptomyces from insect microbiomes

Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.

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Autores principales: Marc G. Chevrette, Caitlin M. Carlson, Humberto E. Ortega, Chris Thomas, Gene E. Ananiev, Kenneth J. Barns, Adam J. Book, Julian Cagnazzo, Camila Carlos, Will Flanigan, Kirk J. Grubbs, Heidi A. Horn, F. Michael Hoffmann, Jonathan L. Klassen, Jennifer J. Knack, Gina R. Lewin, Bradon R. McDonald, Laura Muller, Weilan G. P. Melo, Adrián A. Pinto-Tomás, Amber Schmitz, Evelyn Wendt-Pienkowski, Scott Wildman, Miao Zhao, Fan Zhang, Tim S. Bugni, David R. Andes, Monica T. Pupo, Cameron R. Currie
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/854e622dbc4346adb3d1e484ca48f081
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spelling oai:doaj.org-article:854e622dbc4346adb3d1e484ca48f0812021-12-02T14:39:40ZThe antimicrobial potential of Streptomyces from insect microbiomes10.1038/s41467-019-08438-02041-1723https://doaj.org/article/854e622dbc4346adb3d1e484ca48f0812019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08438-0https://doaj.org/toc/2041-1723Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.Marc G. ChevretteCaitlin M. CarlsonHumberto E. OrtegaChris ThomasGene E. AnanievKenneth J. BarnsAdam J. BookJulian CagnazzoCamila CarlosWill FlaniganKirk J. GrubbsHeidi A. HornF. Michael HoffmannJonathan L. KlassenJennifer J. KnackGina R. LewinBradon R. McDonaldLaura MullerWeilan G. P. MeloAdrián A. Pinto-TomásAmber SchmitzEvelyn Wendt-PienkowskiScott WildmanMiao ZhaoFan ZhangTim S. BugniDavid R. AndesMonica T. PupoCameron R. CurrieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marc G. Chevrette
Caitlin M. Carlson
Humberto E. Ortega
Chris Thomas
Gene E. Ananiev
Kenneth J. Barns
Adam J. Book
Julian Cagnazzo
Camila Carlos
Will Flanigan
Kirk J. Grubbs
Heidi A. Horn
F. Michael Hoffmann
Jonathan L. Klassen
Jennifer J. Knack
Gina R. Lewin
Bradon R. McDonald
Laura Muller
Weilan G. P. Melo
Adrián A. Pinto-Tomás
Amber Schmitz
Evelyn Wendt-Pienkowski
Scott Wildman
Miao Zhao
Fan Zhang
Tim S. Bugni
David R. Andes
Monica T. Pupo
Cameron R. Currie
The antimicrobial potential of Streptomyces from insect microbiomes
description Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.
format article
author Marc G. Chevrette
Caitlin M. Carlson
Humberto E. Ortega
Chris Thomas
Gene E. Ananiev
Kenneth J. Barns
Adam J. Book
Julian Cagnazzo
Camila Carlos
Will Flanigan
Kirk J. Grubbs
Heidi A. Horn
F. Michael Hoffmann
Jonathan L. Klassen
Jennifer J. Knack
Gina R. Lewin
Bradon R. McDonald
Laura Muller
Weilan G. P. Melo
Adrián A. Pinto-Tomás
Amber Schmitz
Evelyn Wendt-Pienkowski
Scott Wildman
Miao Zhao
Fan Zhang
Tim S. Bugni
David R. Andes
Monica T. Pupo
Cameron R. Currie
author_facet Marc G. Chevrette
Caitlin M. Carlson
Humberto E. Ortega
Chris Thomas
Gene E. Ananiev
Kenneth J. Barns
Adam J. Book
Julian Cagnazzo
Camila Carlos
Will Flanigan
Kirk J. Grubbs
Heidi A. Horn
F. Michael Hoffmann
Jonathan L. Klassen
Jennifer J. Knack
Gina R. Lewin
Bradon R. McDonald
Laura Muller
Weilan G. P. Melo
Adrián A. Pinto-Tomás
Amber Schmitz
Evelyn Wendt-Pienkowski
Scott Wildman
Miao Zhao
Fan Zhang
Tim S. Bugni
David R. Andes
Monica T. Pupo
Cameron R. Currie
author_sort Marc G. Chevrette
title The antimicrobial potential of Streptomyces from insect microbiomes
title_short The antimicrobial potential of Streptomyces from insect microbiomes
title_full The antimicrobial potential of Streptomyces from insect microbiomes
title_fullStr The antimicrobial potential of Streptomyces from insect microbiomes
title_full_unstemmed The antimicrobial potential of Streptomyces from insect microbiomes
title_sort antimicrobial potential of streptomyces from insect microbiomes
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/854e622dbc4346adb3d1e484ca48f081
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