Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.

<h4>Objective</h4>To examine the age and sex-specific associations of urine levels of six mono-phthalates with body size and fat distribution in Chinese children at puberty.<h4>Materials and methods</h4>Four hundred and ninety-three school-aged children (247 boys, 246 girls)...

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Autores principales:	Yunhui Zhang, Xiangzhou Meng, Li Chen, Dan Li, Lifang Zhao, Yan Zhao, Luxi Li, Huijing Shi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85513f561a414f0188bb0486743df024
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spelling	oai:doaj.org-article:85513f561a414f0188bb0486743df0242021-11-25T06:04:45ZAge and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.1932-620310.1371/journal.pone.0104852https://doaj.org/article/85513f561a414f0188bb0486743df0242014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25121758/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To examine the age and sex-specific associations of urine levels of six mono-phthalates with body size and fat distribution in Chinese children at puberty.<h4>Materials and methods</h4>Four hundred and ninety-three school-aged children (247 boys, 246 girls) were recruited. Obesity related anthropometric indices were measured and body fat proportion (BF%) was calculated. Spot urine samples were collected and phthalate monoesters were detected by an API 2000 electrospray triple quadrupole mass spectrometer (ESI-MS/MS). Associations between phthalate exposure and overweight/obesity measures and their trends were examined by multiple linear regression and Logistic regression analyses, respectively.<h4>Results</h4>Di-2-ethylhexyl phthalate (DEHP) metabolites and monobutyl phthalate (MBP) were found to be the most detectable chemicals. In 8-10 years (yrs) group, concentrations of MEHP and MBP were significantly higher in girls than those in boys. However, concentrations of all phthalate monoesters, except for MEP and MEHP, in 11-13 yrs boys were significantly higher than those in girls. After adjusting for confounders including puberty onset, urinary concentrations of MBP and sum of low molecular-weight phthalate metabolites (∑LMP) were positively associated with boys' obesity in a concentration-effect manner, while concentrations of MEHP, MEHHP and sum of DEHP metabolites (∑MEHP) were negatively associated with girls' obesity. Associations between phthalate exposure levels and BMI z-score changes were age- and sex-specific in school-age children.<h4>Conclusion</h4>There are age and sex-specific concentration-effect associations between phthalate exposure and fat distribution in Chinese children. Urinary phthalate levels in 11-13 yrs boys were about 30 percent higher than those in girls, and ∑MEHP levels in younger boys (<10 yrs) were significantly higher than those in elder boys (>10 yrs). Associations were positive for MBP and ∑LMP with both BMI z-score and fat distribution in boys >10 years of age, and negative for ∑MEHP with fat distribution in girls <10 years of age.Yunhui ZhangXiangzhou MengLi ChenDan LiLifang ZhaoYan ZhaoLuxi LiHuijing ShiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104852 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yunhui Zhang Xiangzhou Meng Li Chen Dan Li Lifang Zhao Yan Zhao Luxi Li Huijing Shi Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.
description	<h4>Objective</h4>To examine the age and sex-specific associations of urine levels of six mono-phthalates with body size and fat distribution in Chinese children at puberty.<h4>Materials and methods</h4>Four hundred and ninety-three school-aged children (247 boys, 246 girls) were recruited. Obesity related anthropometric indices were measured and body fat proportion (BF%) was calculated. Spot urine samples were collected and phthalate monoesters were detected by an API 2000 electrospray triple quadrupole mass spectrometer (ESI-MS/MS). Associations between phthalate exposure and overweight/obesity measures and their trends were examined by multiple linear regression and Logistic regression analyses, respectively.<h4>Results</h4>Di-2-ethylhexyl phthalate (DEHP) metabolites and monobutyl phthalate (MBP) were found to be the most detectable chemicals. In 8-10 years (yrs) group, concentrations of MEHP and MBP were significantly higher in girls than those in boys. However, concentrations of all phthalate monoesters, except for MEP and MEHP, in 11-13 yrs boys were significantly higher than those in girls. After adjusting for confounders including puberty onset, urinary concentrations of MBP and sum of low molecular-weight phthalate metabolites (∑LMP) were positively associated with boys' obesity in a concentration-effect manner, while concentrations of MEHP, MEHHP and sum of DEHP metabolites (∑MEHP) were negatively associated with girls' obesity. Associations between phthalate exposure levels and BMI z-score changes were age- and sex-specific in school-age children.<h4>Conclusion</h4>There are age and sex-specific concentration-effect associations between phthalate exposure and fat distribution in Chinese children. Urinary phthalate levels in 11-13 yrs boys were about 30 percent higher than those in girls, and ∑MEHP levels in younger boys (<10 yrs) were significantly higher than those in elder boys (>10 yrs). Associations were positive for MBP and ∑LMP with both BMI z-score and fat distribution in boys >10 years of age, and negative for ∑MEHP with fat distribution in girls <10 years of age.
format	article
author	Yunhui Zhang Xiangzhou Meng Li Chen Dan Li Lifang Zhao Yan Zhao Luxi Li Huijing Shi
author_facet	Yunhui Zhang Xiangzhou Meng Li Chen Dan Li Lifang Zhao Yan Zhao Luxi Li Huijing Shi
author_sort	Yunhui Zhang
title	Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.
title_short	Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.
title_full	Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.
title_fullStr	Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.
title_full_unstemmed	Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.
title_sort	age and sex-specific relationships between phthalate exposures and obesity in chinese children at puberty.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/85513f561a414f0188bb0486743df024
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Age and sex-specific relationships between phthalate exposures and obesity in Chinese children at puberty.

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