Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2

Rapid antigen tests (RATs) for COVID-19 based on lateral flow immunoassays are useful for rapid diagnosis in a variety of settings. Although many kinds of RATs are available, their respective sensitivity has not been compared. Here, we examined the sensitivity of 27 RATs available in Japan for the d...

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Autores principales:	Yuko Sakai-Tagawa, Seiya Yamayoshi, Peter J. Halfmann, Yoshihiro Kawaoka
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 COVID-19 rapid antigen test sensitivity delta variant B.1.617.2 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/8553804083414326bc8194d3b5a8f53b
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spelling	oai:doaj.org-article:8553804083414326bc8194d3b5a8f53b2021-11-25T19:13:10ZComparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-210.3390/v131121831999-4915https://doaj.org/article/8553804083414326bc8194d3b5a8f53b2021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2183https://doaj.org/toc/1999-4915Rapid antigen tests (RATs) for COVID-19 based on lateral flow immunoassays are useful for rapid diagnosis in a variety of settings. Although many kinds of RATs are available, their respective sensitivity has not been compared. Here, we examined the sensitivity of 27 RATs available in Japan for the detection of the SARS-CoV-2 delta variant. All of the RATs tested detected the delta variant albeit with different sensitivities. Nine RATs (ESPLINE SARS-CoV-2, ALSONIC COVID-19 Ag, COVID-19 and Influenza A+B Antigen Combo Rapid Test, ImmunoArrow SARS-CoV-2, Fuji Dri-chem immuno AG cartridge COVID-19 Ag, 2019-nCoV Ag rapid detection kit, Saliva SARS-CoV-2(2019-nCoV) Antigen Test Kit, and Rabliss SARS-CoV-2 antigen detection kit COVID19 AG) showed superior sensitivity to the isolated delta variant. Although actual clinical specimens were not examined, the detection level of most of the RATs was 7500 pfu, indicating that individuals whose test samples contained less virus than that would be considered negative. Therefore, it is important to bear in mind that RATs may miss individuals shedding low levels of infectious virus.Yuko Sakai-TagawaSeiya YamayoshiPeter J. HalfmannYoshihiro KawaokaMDPI AGarticleSARS-CoV-2COVID-19rapid antigen testsensitivitydelta variantB.1.617.2MicrobiologyQR1-502ENViruses, Vol 13, Iss 2183, p 2183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 COVID-19 rapid antigen test sensitivity delta variant B.1.617.2 Microbiology QR1-502
spellingShingle	SARS-CoV-2 COVID-19 rapid antigen test sensitivity delta variant B.1.617.2 Microbiology QR1-502 Yuko Sakai-Tagawa Seiya Yamayoshi Peter J. Halfmann Yoshihiro Kawaoka Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
description	Rapid antigen tests (RATs) for COVID-19 based on lateral flow immunoassays are useful for rapid diagnosis in a variety of settings. Although many kinds of RATs are available, their respective sensitivity has not been compared. Here, we examined the sensitivity of 27 RATs available in Japan for the detection of the SARS-CoV-2 delta variant. All of the RATs tested detected the delta variant albeit with different sensitivities. Nine RATs (ESPLINE SARS-CoV-2, ALSONIC COVID-19 Ag, COVID-19 and Influenza A+B Antigen Combo Rapid Test, ImmunoArrow SARS-CoV-2, Fuji Dri-chem immuno AG cartridge COVID-19 Ag, 2019-nCoV Ag rapid detection kit, Saliva SARS-CoV-2(2019-nCoV) Antigen Test Kit, and Rabliss SARS-CoV-2 antigen detection kit COVID19 AG) showed superior sensitivity to the isolated delta variant. Although actual clinical specimens were not examined, the detection level of most of the RATs was 7500 pfu, indicating that individuals whose test samples contained less virus than that would be considered negative. Therefore, it is important to bear in mind that RATs may miss individuals shedding low levels of infectious virus.
format	article
author	Yuko Sakai-Tagawa Seiya Yamayoshi Peter J. Halfmann Yoshihiro Kawaoka
author_facet	Yuko Sakai-Tagawa Seiya Yamayoshi Peter J. Halfmann Yoshihiro Kawaoka
author_sort	Yuko Sakai-Tagawa
title	Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
title_short	Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
title_full	Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
title_fullStr	Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
title_full_unstemmed	Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2
title_sort	comparative sensitivity of rapid antigen tests for the delta variant (b.1.617.2) of sars-cov-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8553804083414326bc8194d3b5a8f53b
work_keys_str_mv	AT yukosakaitagawa comparativesensitivityofrapidantigentestsforthedeltavariantb16172ofsarscov2 AT seiyayamayoshi comparativesensitivityofrapidantigentestsforthedeltavariantb16172ofsarscov2 AT peterjhalfmann comparativesensitivityofrapidantigentestsforthedeltavariantb16172ofsarscov2 AT yoshihirokawaoka comparativesensitivityofrapidantigentestsforthedeltavariantb16172ofsarscov2
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Comparative Sensitivity of Rapid Antigen Tests for the Delta Variant (B.1.617.2) of SARS-CoV-2

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